{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:38:40Z","timestamp":1761863920936,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["20140442","201803010009","2018A030313600"],"award-info":[{"award-number":["20140442","201803010009","2018A030313600"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["20140442","201803010009","2018A030313600"],"award-info":[{"award-number":["20140442","201803010009","2018A030313600"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["20140442","201803010009","2018A030313600"],"award-info":[{"award-number":["20140442","201803010009","2018A030313600"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,9,24]]},"abstract":"<jats:p>YA is an angiotensin-I-converting enzyme- (ACE-) inhibitory peptide from oyster hydrolysate with antihypertensive activity. Its antioxidant and anti-inflammatory activity were investigated in this study. YA can dose-dependently quench DPPH and ABTS radical and inhibit lipopolysaccharide-induced nitric oxide in RAW 264.7 cells. YA is a multifunctional peptide and was selected as an indicator for quality control and efficacy evaluation of oyster hydrolysate. A practical HPLC\/UV assay for YA quantification was developed and validated. It was proved to be accurate and reliable, according to parameters such as specificity, linearity, precision, and accuracy. The quantity results of YA showed that the stage of enzymatic hydrolysis was a critical control point for quality control; the efficacy of oyster hydrolysate can be enhanced after digested in the gastrointestinal tract due to the release of YA by brush border peptidases. Therefore, YA from oyster hydrolysate is a potential bioactive ingredient for functional foods to combat hypertension.<\/jats:p>","DOI":"10.1155\/2018\/8437379","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T19:31:35Z","timestamp":1537817495000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Quantification of Multifunctional Dipeptide YA from Oyster Hydrolysate for Quality Control and Efficacy Evaluation"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-2067","authenticated-orcid":true,"given":"Cheng-Liang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Medical Statistics and Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangdong Engineering Technology Research Center of Nutrition Translation, School of Public Health, Sun Yat-Sen University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-2067","authenticated-orcid":true,"given":"Sang Soo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-4967","authenticated-orcid":true,"given":"Ciyong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Epidemiology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangdong Engineering Technology Research Center of Nutrition Translation, School of Public Health, Sun Yat-Sen University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-4991","authenticated-orcid":true,"given":"Yeung Joon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Seafood Science and Technology\/Institute of Marine Industry, Gyeongsang National University, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1021\/jf204118n"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.03.018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000203189.57513.76"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S148911"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.39"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2006.10.004"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.07.019"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.07.010"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1021\/jf102538g"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2634"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-6946(02)00077-8"},{"key":"12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1749-8546-3-7","volume":"3","year":"2008","journal-title":"Chinese Medicine"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.13207"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.05.029"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/379234"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2009.12.004"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.08.013"},{"year":"1996","key":"18"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2011.01.008"},{"issue":"1","key":"20","first-page":"23","volume":"3","year":"2009","journal-title":"Records of Natural Products"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/psc.1345"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1021\/jf950833m"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.01.007"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.10.053"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2317fje"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1039\/c5fo01302j"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-2244(01)00007-3"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2005.03.012"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1385\/1592597424"},{"first-page":"111","volume-title":"Liquid chromatography-mass spectrometry and tandem mass spectrometry of peptides and proteins","year":"2004","key":"30"},{"year":"2010","key":"31"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1021\/pr9001417"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-375680-0.00011-5"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1080\/10826070701435145"},{"issue":"1","key":"35","first-page":"7","volume":"47","year":"2013","journal-title":"Indian Journal of Pharmaceutical Education and Research (IJPER)"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.1228"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.917077"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200600422"},{"first-page":"411","volume-title":"Dietary protein processing: intraluminal and enterocyte surface events","year":"1991","key":"39"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8437379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8437379.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8437379.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T19:31:38Z","timestamp":1537817498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/8437379\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":39,"alternative-id":["8437379","8437379"],"URL":"https:\/\/doi.org\/10.1155\/2018\/8437379","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2018,9,24]]}}}