{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:29:37Z","timestamp":1761391777567,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201074"],"award-info":[{"award-number":["81201074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2018,12,20]]},"abstract":"<jats:p><jats:italic>Purposes<\/jats:italic>. Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma. In this work, radiosynthesis of [<jats:sup>18<\/jats:sup>F]-fluoropropionyl-chlorotoxin ([<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin) as a novel PET tracer was investigated, and biodistribution in vivo and PET imaging were performed in the C6 glioma model. <jats:italic>Procedures<\/jats:italic>. [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin was prepared from the reaction of chlorotoxin with [<jats:sup>18<\/jats:sup>F]-NFB (4-nitrophenyl 2-[<jats:sup>18<\/jats:sup>F]-fluoropropionate), which was synthesized from multistep reactions. Biodistribution was determined in 20 normal Kunming mice. Small-animal PET imaging with [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin was performed on the same rats bearing orthotopic C6 glioma at different time points (60\u2009min, 90\u2009min, and 120\u2009min) after injection and compared with 2-deoxy-2-[<jats:sup>18<\/jats:sup>F] fluoro-D-glucose ([<jats:sup>18<\/jats:sup>F]-FDG). <jats:italic>Results<\/jats:italic>. [<jats:sup>18<\/jats:sup>F]-FP-Chlorotoxin was successfully synthesized in the radiochemical yield of 41% and the radiochemical purity of more than 98%. Among all the organs, the brain had the lowest and stable uptake of [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin, while the kidney showed the highest uptake. Compared with [<jats:sup>18<\/jats:sup>F]-FDG, a low uptake of [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin was detected in normal brain parenchyma and a high accumulation of [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin was found in the gliomas tissue. The glioma to normal brain uptake ratio of [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin was higher than that of [<jats:sup>18<\/jats:sup>F]-FDG. Furthermore, the uptake of [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin at 90\u2009min after injection was better than that at 60\u2009min after injection. <jats:italic>Conclusions<\/jats:italic>. Compared with [<jats:sup>18<\/jats:sup>F]-FDG, [<jats:sup>18<\/jats:sup>F]-FP-chlorotoxin has a low and stable uptake in normal brain parenchyma. [<jats:sup>18<\/jats:sup>F]-FP-Chlorotoxin seems to be a potential PET tracer with a good performance in diagnosis of the glioma.<\/jats:p>","DOI":"10.1155\/2018\/8439162","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T18:43:03Z","timestamp":1545331383000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["Radiosynthesis and Preliminary Biological Evaluation of <sup>18<\/sup>F-Fluoropropionyl-Chlorotoxin as a Potential PET Tracer for Glioma Imaging"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9270-3250","authenticated-orcid":true,"given":"Jing","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shenzhen City 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Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-8257","authenticated-orcid":true,"given":"Yu-kun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Research Center for 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