{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:52:07Z","timestamp":1753887127798,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":329,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273713"],"award-info":[{"award-number":["81273713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["08KJD360004"],"award-info":[{"award-number":["08KJD360004"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Introduction.<\/jats:italic> Hypertensive renal damage is a chronic and life\u2010threatening kidney disease all over the world. The traditional Chinese medicine Jiang Ya Yi Shen (JYYS) granule has been a perfect drug for patients with hypertensive renal injury in clinic for 20 years in China. However, the molecular mechanism of JYYS granule remains unknown in treatment of this disease. <jats:italic>Methods.<\/jats:italic> The clinic data were from this study\u2019s patients. The clinical symptoms of patients were indicated by (N\u2010Acetyl\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010Glucosaminidase) NAG, (albumin) Alb, and (<jats:italic>\u03b2<\/jats:italic>2\u2010microglobin) <jats:italic>\u03b2<\/jats:italic>2\u2010MG content in urinary of patients, and renal artery\u2019s hemodynamic parameters including (pulse index) PI, mean velocity of the arterial blood (Vm), minimum velocity of the diastolic stage (Vdmin) and peak velocity of the systolic wave (Vsmax). To further observe the effect of JYYS granule on renal damage, the rats were included in six groups: normal rats (WKY), spontaneously hypertensive rats (SHR), positive drug\u2010treated rats (Benazepril), low dose JYYS (L), middle dose JYYS (M), and high dose JYYS (H). Then, we observed the effect of JYYS on renal function, renal tubules, inflammatory cell infiltration, and small artery thickening, and we explored the potential mechanism of JYYS in treatment of renal injury. <jats:italic>Results.<\/jats:italic> JYYS significantly improved the clinic symptoms of patients with hypertensive nephropathy by downregulating NAG, Alb, and <jats:italic>\u03b2<\/jats:italic>2\u2010MG content in urinary of patients and by decreasing renal artery\u2019s hemodynamic parameters including PI, Vm, Vdmin, and Vsmax. In SHR, JYYS significantly improved renal function including creatinine clearance rate, urinary albumin\/creatinine, <jats:italic>\u03b2<\/jats:italic>2\u2010MG\/creatinine and arteria caudalis pressure in SHR. Secondly, light and electron microscopic examinations told that after administration of JYYS and Benazepril, the mesangial region exhibited no hyperplasia and renal capsule did not expanded, and there no abnormalities were observed in renal tubules, inflammatory cell infiltration and small artery thickening in SHR. Thirdly, JYYS exhibited its protective role by inhibiting nuclear factor kappa beta signaling\u2010mediated micro\u2010inflammation cytokines including interleukin 6 (IL\u20106), tumor necrosis factor <jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>), intercellular cell adhesion molecule\u20101 (ICAM\u20101), and monocyte chemotactic protein 1 (MCP\u20101) in SHR. <jats:italic>Conclusion.<\/jats:italic> JYYS is a promising prescription of Chinese medicine for patients with hypertension and hypertensive renal damage.<\/jats:p>","DOI":"10.1155\/2018\/8472963","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T23:31:23Z","timestamp":1543275083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["JYYS Granule Mitigates Renal Injury in Clinic and in Spontaneously Hypertensive Rats by Inhibiting NF\u2010<i>\u03ba<\/i>B Signaling\u2010Mediated Microinflammation"],"prefix":"10.1155","volume":"2018","author":[{"given":"Dong","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muyan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihai","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-1277","authenticated-orcid":false,"given":"Yuliang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-6937","authenticated-orcid":false,"given":"Zhuyuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_1_2","DOI":"10.1042\/bsr20160035"},{"doi-asserted-by":"publisher","key":"e_1_2_10_2_2","DOI":"10.1016\/S2213-8587(16)00033-4"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_2","DOI":"10.1093\/ndt\/gfv101"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_2","DOI":"10.3109\/0886022X.2014.934692"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_2","DOI":"10.1038\/sj.ki.5001603"},{"key":"e_1_2_10_6_2","first-page":"87","article-title":"Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma(PPAR-\u03b3)","volume":"62","author":"Miana M.","year":"2011","journal-title":"Journal of Physiology and Pharmacology"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_2","DOI":"10.1124\/jpet.114.218370"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_2","DOI":"10.1371\/journal.pone.0158908"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_2","DOI":"10.1177\/1535370214565970"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_2","DOI":"10.1016\/j.lfs.2015.01.005"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_2","DOI":"10.1007\/s12026-014-8548-6"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_2","DOI":"10.1038\/hr.2013.99"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_2","DOI":"10.1159\/000480198"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_2","DOI":"10.3892\/mmr.2011.717"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_2","DOI":"10.1016\/j.omtn.2017.12.006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_2","DOI":"10.1681\/ASN.2006070770"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_2","DOI":"10.1007\/s11010-015-2439-6"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_2","DOI":"10.1016\/j.pedneo.2013.09.005"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_2","DOI":"10.3389\/fphar.2018.00444"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_2","DOI":"10.4268\/cjcmm20141805"},{"key":"e_1_2_10_21_2","first-page":"249","article-title":"Current status and prospects of integrated traditional Chinese and Western medicine for treatment of portal hypertension","volume":"26","author":"Wang J.","year":"2018","journal-title":"Chinese Journal of Hepatology"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_2","DOI":"10.3736\/jcim20040608"},{"key":"e_1_2_10_23_2","first-page":"279","article-title":"Observation on 104 senile chronic renal insufficiency patients treated with integrated traditional Chinese and Western medicine","volume":"14","author":"Zhang S. 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