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In this study, we aimed to illustrate the preventive effect and possible mechanisms of Feiyangchangweiyan capsule (FYCWYC) on rat pelvic inflammatory disease (PID) model. <jats:italic>Methods<\/jats:italic>. To construct the rat PID model, upper genital tract was infected by multipathogen, and then drugs were orally administered for 8 days. The histological examination, immunohistochemical analysis, and ELISA were carried out. Furthermore, Western blotting was used to analyze the expression of Akt, MAPKs, NF\u2010<jats:italic>\u03ba<\/jats:italic>B p65, and I<jats:italic>\u03ba<\/jats:italic>B\u2010<jats:italic>\u03b1<\/jats:italic> in uterus. <jats:italic>Results<\/jats:italic>. As the results showed, infiltrations of neutrophils and lymphocytes in uterus were significantly suppressed, and IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, CXCL\u20101, and TNF\u2010<jats:italic>\u03b1<\/jats:italic> were also reduced in a dose\u2010dependent manner. We also found that FYCWYC inhibited apoptosis induced by infection. Furthermore, FYCWYC could block the infection\u2010induced nuclear translocation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B. We found that FYCWYC treatment only decreased the phosphorylation of JNK induced by infection and had no effects on Akt and P38. Additional, the effects of SP600125, an inhibitor of phospho\u2010JNK, were similar to the results of FYCWYC. <jats:italic>Conclusions<\/jats:italic>. Taken together, our results demonstrated that FYCWYC had anti\u2010inflammatory effect in pathogen\u2010induced PID model, and the mechanism might be through inhibiting NF\u2010<jats:italic>\u03ba<\/jats:italic>B nuclear translocation which is mediated by JNK.<\/jats:p>","DOI":"10.1155\/2018\/8476147","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T23:45:29Z","timestamp":1519861529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti\u2010Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNK\/NF\u2010<i>\u03ba<\/i>B Pathway"],"prefix":"10.1155","volume":"2018","author":[{"given":"Yao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-265X","authenticated-orcid":false,"given":"Yanhua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-4716","authenticated-orcid":false,"given":"Siwang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_2_9_1_2","volume-title":"Suaray M: Pelvic Inflammatory Disease","author":"Barash J. 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