{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:24:10Z","timestamp":1790745850640,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the performance of serum and urinary sCD163 concentrations as possible biomarker in systemic sclerosis (SSc). <jats:italic>Methods<\/jats:italic>. Urine and serum samples were obtained from SSc patients and age- and sex-matched controls. Serum and urinary sCD163 concentrations were measured by commercially available ELISA kit. SSc patients were assessed following international guidelines. Cross-sectional analyses were performed. <jats:italic>Results<\/jats:italic>. Two hundred and three SSc patients were included. The control group consisted of 47 age- and sex-matched patients having noninflammatory diseases, mainly osteoporosis. Serum sCD163 levels were significantly higher in SSc patients compared with controls (mean\u2009\u00b1\u2009SD: 529\u2009\u00b1\u2009251 versus 385\u2009\u00b1\u2009153\u2009ng\/mL; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Urinary sCD163 concentrations were higher in SSc patients than controls, but this did not reach significance (236\u2009\u00b1\u2009498 versus 176\u2009\u00b1\u2009173\u2009ng\/mg uCr; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.580<\/mml:mn><\/mml:math>). The sCD163 concentrations were not associated with clinical, laboratory, and instrumental characteristics of SSc patients. <jats:italic>Conclusion<\/jats:italic>. To our knowledge, this is the first evaluation of both serum and urinary sCD163 levels in SSc. Our results show a significant difference for sera values that should be prioritized for further studies as compared to urinary measurements. Our results further support that the M2 macrophages\/CD163 signaling system may play a role in the pathogenesis of SSc, although we could not identify a subset of SSc patients with higher concentrations.<\/jats:p>","DOI":"10.1155\/2018\/8509583","type":"journal-article","created":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T19:34:17Z","timestamp":1522611257000},"page":"1-5","source":"Crossref","is-referenced-by-count":37,"title":["Soluble CD163 as a Potential Biomarker in Systemic Sclerosis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Camelia","family":"Frantz","sequence":"first","affiliation":[{"name":"Inserm U1016, UMR8104, Rheumatology A Department, Cochin Hospital, Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Pezet","sequence":"additional","affiliation":[{"name":"Inserm U1016, UMR8104, Rheumatology A Department, Cochin Hospital, Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Avouac","sequence":"additional","affiliation":[{"name":"Inserm U1016, UMR8104, Rheumatology A Department, Cochin Hospital, Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-0002","authenticated-orcid":true,"given":"Yannick","family":"Allanore","sequence":"additional","affiliation":[{"name":"Inserm U1016, UMR8104, Rheumatology A Department, Cochin Hospital, Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.10.010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker269"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-015-0554-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210823"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/35051594"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7303"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/ar3066"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-012-0076-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-1972-x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1691-z"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2016.15088"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw214"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015050511"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"issue":"2","key":"17","first-page":"202","volume":"15","year":"1988","journal-title":"The Journal of Rheumatology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.6.592"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.5301\/jsrd.5000231"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.136929"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/art.40377"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2018\/8509583.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2018\/8509583.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2018\/8509583.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T19:34:20Z","timestamp":1522611260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2018\/8509583\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":21,"alternative-id":["8509583","8509583"],"URL":"https:\/\/doi.org\/10.1155\/2018\/8509583","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}