{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:30:39Z","timestamp":1782275439387,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Health System Key Joint Research Project on Important Diseases of the Second Allocation","award":["2014ZYJB0010"],"award-info":[{"award-number":["2014ZYJB0010"]}]},{"name":"Shanghai Health System Key Joint Research Project on Important Diseases of the Second Allocation","award":["2015ZB0501"],"award-info":[{"award-number":["2015ZB0501"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning, Key Developing Disciplines","award":["2014ZYJB0010"],"award-info":[{"award-number":["2014ZYJB0010"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning, Key Developing Disciplines","award":["2015ZB0501"],"award-info":[{"award-number":["2015ZB0501"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>This study aimed to investigate the characteristics of Chinese patients with Beh\u00e7et disease (BD) and myelodysplastic syndrome (MDS) and explore the role played by trisomy 8. This was a retrospective study of patients with BD and MDS from the Shanghai Beh\u00e7et\u2019s disease database who were diagnosed between October 2012 and July 2017. There were 805 patients with BD and 16 also had MDS. Trisomy 8 was examined in patients with BD-MDS and some patients with gastrointestinal (GI) BD. Patients with BD and MDS (16\/805; 2%) were more likely to be female and older; display fever and intestinal lesions; have lower leukocyte count, hemoglobin, platelet count; and show higher C-reactive protein and erythrocyte sedimentation rate (ESR) than patients with BD without MDS (all <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Trisomy 8 was common (81.3%) in patients with BD-MDS. Ulcers in the ileocecal region were more frequently seen in intestinal patients with BD-MDS than in BD without MDS (90.0% versus 48.9%; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.032<\/mml:mn><\/mml:math>). GI ulceration is common in patients with BD-MDS. Cytogenetic aberrations, especially trisomy 8, may play a role in the pathogenesis of intestinal involvement in patients with BD-MDS.<\/jats:p>","DOI":"10.1155\/2018\/8535091","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T19:33:16Z","timestamp":1524598396000},"page":"1-8","source":"Crossref","is-referenced-by-count":29,"title":["High Incidence of Gastrointestinal Ulceration and Cytogenetic Aberration of Trisomy 8 as Typical Features of Beh\u00e7et\u2019s Disease Associated with Myelodysplastic Syndrome: A Series of 16 Consecutive Chinese Patients from the Shanghai Beh\u00e7et\u2019s Disease Database and Comparison with the Literature"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9744-3224","authenticated-orcid":true,"given":"Yan","family":"Shen","sequence":"first","affiliation":[{"name":"Division of Immunology and Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-0865","authenticated-orcid":true,"given":"Hai-Fen","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0663-1706","authenticated-orcid":true,"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-6690","authenticated-orcid":true,"given":"Jian-Fei","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9563-2702","authenticated-orcid":true,"given":"Jun","family":"Zou","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-480X","authenticated-orcid":true,"given":"Jian-Long","family":"Guan","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462981922449"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199910213411707"},{"key":"3","first-page":"145","volume":"33","year":"2015","journal-title":"Clinical and Experimental Rheumatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80001-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.6.411"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(79)90004-0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200003000-00006"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.18.6.491"},{"key":"9","volume-title":"Behcet's disease: gastrointestinal involvement","year":"2010"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.3.208"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-010-0370-y"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23642"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-5710(97)00042-X"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1385\/MO:23:3:385"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh136"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20504"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097683"},{"issue":"5, supplement 42","key":"18","first-page":"S115","volume":"24","year":"2006","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"1","key":"19","first-page":"76","volume":"31","year":"2013","journal-title":"Clinical and Experimental Rheumatology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1718"},{"issue":"2","key":"21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1046\/j.1365-2141.2000.01868.x","volume":"108","year":"2000","journal-title":"British Journal of Haematology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403806"},{"issue":"4","key":"23","first-page":"706","volume":"26","year":"2008","journal-title":"Clinical and Experimental Rheumatology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32756"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken162"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1319-3"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2015.13.2.166"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-003-0245-6"},{"issue":"6","key":"29","first-page":"365","volume":"69","year":"2015","journal-title":"Acta Medica Okayama"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1159\/000355341"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.3.389"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1556"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12269"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92643-v"},{"issue":"3","key":"35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.12107","volume":"28","year":"2014","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.08.008"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-031351"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.07.006"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2014.29.1.123"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-010-0291-9"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181776bde"},{"issue":"2","key":"42","first-page":"S85","volume":"27","year":"2009","journal-title":"Clinical and Experimental Rheumatology"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2009.n.090"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s100670170036"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0103"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1080\/030097402320318387"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2010.02.009"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970115)79:2<262::AID-CNCR9>3.0.CO;2-M"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.1909"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(97)00456-1"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8535091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8535091.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8535091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T19:33:23Z","timestamp":1524598403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/8535091\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":50,"alternative-id":["8535091","8535091"],"URL":"https:\/\/doi.org\/10.1155\/2018\/8535091","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}