{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:11:13Z","timestamp":1773378673383,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hepatology"],"published-print":{"date-parts":[[2018,10,22]]},"abstract":"<jats:p>Liver involvement is a known feature of secondary syphilis. The prevalence of hepatitis in secondary syphilis ranges broadly from 1 to 50%. We report a case of a 37-year-old man with type 1 diabetes mellitus and sickle cell trait presenting with jaundice and acute liver cholestasis. Abdominal ultrasound revealed mild hepatic fatty infiltration. RPR and Treponema pallidum IgG results were positive with a reflex titer of 1:64. Liver biopsy revealed chronic hepatitis with normal hepatic architecture, Kupffer cell hyperplasia, hepatic cholestasis, and ductal proliferation suggestive of syphilitic hepatitis.<\/jats:p>","DOI":"10.1155\/2018\/8645068","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T19:43:06Z","timestamp":1540237386000},"page":"1-3","source":"Crossref","is-referenced-by-count":3,"title":["Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient"],"prefix":"10.1155","volume":"2018","author":[{"given":"Nazneen","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5477-5181","authenticated-orcid":true,"given":"Samuel O.","family":"Igbinedion","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richie","family":"Diaz","sequence":"additional","affiliation":[{"name":"School of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-3711","authenticated-orcid":true,"given":"J. 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