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S\u2010amlodipine (S\u2010AM), an S\u2010enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performed in\u2010depth review of S\u2010AM. This review discusses clinical evidence from total 42 studies (26 randomized controlled trials, 14 observational studies, and 2 meta\u2010analyses) corroborating over 7400 patients treated with S\u2010AM. Efficacy and safety of S\u2010AM in HTN in comparison to racemic amlodipine, used as monotherapy and in combination with other antihypertensives, efficacy in angina, and pleiotropic benefits with S\u2010AM, are discussed in this review.<\/jats:p>","DOI":"10.1155\/2018\/8681792","type":"journal-article","created":{"date-parts":[[2018,5,20]],"date-time":"2018-05-20T19:32:31Z","timestamp":1526844751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["S\u2010Amlodipine: An Isomer with Difference\u2014Time to Shift from Racemic Amlodipine"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-5674","authenticated-orcid":false,"given":"Jamshed","family":"Dalal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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