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HCV infection can determine direct extrahepatic manifestations at the oral and periodontal level including oral lichen planus, Sj\u00f6gren-like sialadenitis, and oral cancer. The changes caused by the infection in the subjects\u2019 immune system, diet, and lifestyle can facilitate the development of oral conditions such as periodontal disease. Important changes also occur in the composition of the infected patients\u2019 saliva and gingival fluid. HCV-infected patients need to be carefully monitored in terms of oral health since the infection with the virus can result in oral complications. The cellular and molecular particularities of the gingival fluid of HCV-infected patients can answer some questions regarding its impact upon periodontium impairment and whether this refers to a possible bidirectional relationship, with hepatic biomarker adjustments being induced by the periodontal patients\u2019 inflammatory status.<\/jats:p>","DOI":"10.1155\/2018\/8720101","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T23:31:26Z","timestamp":1520983886000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["Hepatitis C Infection and Periodontal Disease: Is there a Common Immunological Link?"],"prefix":"10.1155","volume":"2018","author":[{"given":"Dorin Nicolae","family":"Gheorghe","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-0711","authenticated-orcid":true,"given":"Liliana","family":"Foia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Medicine and Pharmacy \u201cGrigore T. 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