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However, its mechanism remains unclear. In the present study, eighty healthy Wistar rats were divided into a normal control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>15<\/mml:mn><\/mml:math>) and premodel group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>65<\/mml:mn><\/mml:math>). Forty-five rats that met the criteria for the AD model were then randomly divided into the model group (MG), the nonacupoint group (NG), and the acupoint group (AG). All rats received positron emission tomography (PET) scanning, and the images were analyzed with Statistical Parametric Mapping 8.0. MG exhibited hypometabolism in the olfactory bulb, insular cortex, orbital cortex, prelimbic cortex, striatum, parietal association cortex, visual cortex, cingulate gyrus, and retrosplenial cortex. AG exhibited prominent and extensive hypermetabolism in the thalamus, hypothalamus, bed nucleus of the stria terminalis, cerebral peduncle, midbrain tegmentum, and pontine tegmentum compared to NG. These results demonstrated that acupuncturing at GV24 and bilateral GB13 acupoints may improve the learning and memory abilities of the AD rats, probably via altering cerebral glucose metabolism (CGM) in the hypothalamus, thalamus, and brain stem. The observed effects of acupuncture may be caused by regulating the distribution of certain kinds of neurotransmitters and enhancing synaptic plasticity.<\/jats:p>","DOI":"10.1155\/2018\/8740284","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T23:31:42Z","timestamp":1525131102000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Cerebral Responses to Acupuncture at GV24 and Bilateral GB13 in Rat Models of Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2018","author":[{"given":"Shaoyang","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China"},{"name":"Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA 02129, 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