{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:23:41Z","timestamp":1778217821147,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2018,6,26]]},"abstract":"<jats:p>Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results. In this cohort, 3,200 patients developed SPM, a substantially higher number than in the reference population of 2,749 with observed to expected ratio (O\/E) of 1.16 (95% CI; 1.12\u20131.21). Bone and joint cancer had the highest O\/E ratio of 4.26 (95% confidence interval [CI] 2.33\u20137.15) followed by salivary gland (O\/E 4.15; 95% CI 2.76\u20136.0) and acute lymphocytic leukemia (O\/E 3.98; 95% CI 2.12\u20136.8). Mean age at the diagnosis of SPM was 64.4 years old. Interestingly, incidence of colorectal cancer was lower in thyroid cancer survivors compared to general population (large intestine O\/E 0.3; 95% CI 0.06\u20130.88, rectum O\/E 0.6; 95% CI 0.41\u20130.85); however, this was not observed in patients who underwent radiation therapy. The incidence of SPM at all sites was higher during 2000\u20132012 compared to 1992\u20131999 (O\/E 1.24 versus 1.10). Surprisingly, patients with micropapillary cancer had higher incidence of SPM than counterparts with a larger tumor in radiation group (O\/E of 1.40 versus 1.15). O\/E of all cancers were higher in males compared to females with O\/E of 1.41 versus 1.17 during the period of 2000\u20132012. Diagnosis of PTC before age 50, especially at age 30\u201334, was associated with higher incidence of overall SPM (age 30\u201334; O\/E 1.43; 95% CI; 1.19\u20131.71). Efficient monitoring strategies that include age at the time of thyroid cancer diagnosis, exposure to radiation, gender, and genetic susceptibility may successfully detect SPM earlier in the disease course. This is especially important given the excellent prognosis of the initial thyroid cancer itself.<\/jats:p>","DOI":"10.1155\/2018\/8765369","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T19:32:57Z","timestamp":1530041577000},"page":"1-11","source":"Crossref","is-referenced-by-count":24,"title":["Incidence of Second Malignancy in Patients with Papillary Thyroid Cancer from Surveillance, Epidemiology, and End Results 13 Dataset"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-0314","authenticated-orcid":true,"given":"Mayumi","family":"Endo","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Ohio State University School of Medicine, 578 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210, USA"},{"name":"Division of Endocrinology, Gerontology and Metabolism, Department of Internal Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Grant S-025, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica B.","family":"Liu","sequence":"additional","affiliation":[{"name":"Perinatal Epidemiology and Health Outcomes Research Unit, Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children\u2019s Hospital, 1265 Welch Road, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelle","family":"Dougan","sequence":"additional","affiliation":[{"name":"Department of Health Science and Recreation, San Jose State University, One Washington Square, San Jose, CA 95192, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Gerontology and Metabolism, Department of Internal Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Grant S-025, Stanford, CA 94305, 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