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We hypothesized that EA attenuates hypertension, in part, through modulation of <jats:italic>\u03b3<\/jats:italic>-aminobutyric acid (GABA) receptor function in the nucleus tractus solitarii (NTS). In the present study, the long-term effect of EA on GABA receptor function and expression was examined in the NTS of two-kidney, one-clip (2K1C) renovascular hypertensive rats. EA (0.1\u20130.4\u2009mA, 2 and 15\u2009Hz) was applied at Zusanli (ST36) acupoints overlying the deep fibular nerve for 30\u2009min once a day for two weeks. The results showed that long-term EA treatment improved blood pressure (BP) and markedly restored the baroreflex response in 2K1C hypertensive rats. The increased pressor and depressor responses to microinjection of GABA<jats:sub>B<\/jats:sub> receptor agonist and antagonist into the NTS in the hypertensive rats were blunted by the EA treatment. Moreover, EA treatment attenuated the increased GABA<jats:sub>B<\/jats:sub> receptor expression in the NTS of hypertensive rats. In contrast, EA had no significant effect on the GABA<jats:sub>A<\/jats:sub> receptor function and expression in the NTS of 2K1C hypertensive rats. These findings suggest that the beneficial effects of EA on renovascular hypertension may be through modulation of functional GABA<jats:sub>B<\/jats:sub> receptors in the NTS.<\/jats:p>","DOI":"10.1155\/2018\/8919347","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T19:32:15Z","timestamp":1538335935000},"page":"1-11","source":"Crossref","is-referenced-by-count":22,"title":["Electroacupuncture Improves Baroreflex and <i>\u03b3<\/i>-Aminobutyric Acid Type B Receptor-Mediated Responses in the Nucleus Tractus Solitarii of Hypertensive Rats"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-1991","authenticated-orcid":true,"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Chinese Medicine Encephalopathy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, 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