{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:26Z","timestamp":1740169766876,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academia Sinica Stroke Biosignature Project","award":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tseng-Lien Lin Foundation (Taiwan)","award":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"]}]},{"name":"Brain Disease Foundation (Taiwan)","award":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"]}]},{"name":"Katsuzo and Kiyo Aoshima Memorial Funds, Japan","award":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123004","BM10701010021","MOST 106-2321-B-039-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Cholangitis is the infectious disease involving the biliary tract, which may induce systemic inflammation. Bone loss is a well-known sequelae after systemic inflammatory disease, and one grave complication after osteoporosis is hip fracture. We want to know whether cholangitis can contribute to increased risk of hip fracture.<jats:italic> Methods<\/jats:italic>. All the patients diagnosed with cholangitis since January 1, 2001, to December 31, 2009, were assessed. All the subjects with cancer history, traumatic accident, and previous fracture were excluded. We selected the controls without cholangitis and matched the controls to cholangitis patients by age, sex, osteoporosis, and the use of steroid for more than 30 days by approximately 1:4 ratio.<jats:italic> Results<\/jats:italic>. There were 2735 subjects in the cholangitis cohort and 10915 in the noncholangitis cohort. There were 101 hip fractures in the cholangitis cohort with the incidence density of 7.58 per 1000 person-years. As for the noncholangitis cohort, 366 individuals suffered from hip fracture with the incidence density of 5.86 per 1000 person-years. The risk of hip fracture was higher in the cholangitis cohort with a 1.29-fold increased risk than the noncholangitis cohort (hazard ratio = 1.29, 95% confidence interval = 1.03-1.61). The association between cholangitis and the hip fracture was more prominent among subjects less than 65 years (hazard ratio = 2.65, 95% confidence interval =1.30-5.39) and the subjects without comorbidities (hazard ratio = 3.01, 95% confidence interval = 1.42-6.41).<jats:italic> Conclusions<\/jats:italic>. Cholangitis is associated with higher risk for hip fracture, especially among young subjects free from medical comorbidities.<\/jats:p>","DOI":"10.1155\/2018\/8928174","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T19:33:01Z","timestamp":1528227181000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Increased Risk for Hip Fractures among Patients with Cholangitis: A Nationwide Population-Based Study"],"prefix":"10.1155","volume":"2018","author":[{"given":"Chieh-Cheng","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horng-Chaung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsuan-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Cheng","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Chun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-4608","authenticated-orcid":true,"given":"Shu-Jui","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0171-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-006-1152-y"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305039"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.04.014"},{"issue":"1","key":"5","first-page":"51","volume":"11","year":"2008","journal-title":"McGill Journal of Medicine"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.5312\/wjo.v5.i4.402","volume":"5","year":"2014","journal-title":"World Journal of Orthopedics"},{"issue":"11","key":"7","first-page":"1619","volume":"25","year":"2015","journal-title":"Clinical Calcium"},{"issue":"1","key":"8","first-page":"79","volume":"100","year":"2009","journal-title":"Minerva Medica"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.014"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.554055"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00178.x"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8928174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8928174.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/8928174.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T19:33:13Z","timestamp":1528227193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/8928174\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":11,"alternative-id":["8928174","8928174"],"URL":"https:\/\/doi.org\/10.1155\/2018\/8928174","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2018,6,5]]}}}