{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:58:40Z","timestamp":1778108320339,"version":"3.51.4"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":352,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503206"],"award-info":[{"award-number":["81503206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Both alterations to the intestinal microflora and chronic systemic inflammation predispose towards type 2 diabetes (T2D). Changes in the composition of the intestinal microflora are associated with glucose metabolism changes in rats with T2D. Here, we demonstrate that a berberine fumarate (BF) has a hypoglycemic effect by regulating the intestinal microflora and metabolism of diabetic rats. The T2D rats had disorders of glucose and lipid metabolism, an abnormal intestinal microflora, fewer butyrate\u2010producing and probiotic\u2010type bacteria, larger numbers of potentially pathogenic and sulfate\u2010reducing bacteria, and tissue inflammation. Administration of berberine fumarate significantly ameliorated the metabolic disorder; increased the populations of Bacteroidetes, Clostridia, Lactobacillales, Prevotellaceae, and Alloprevotella; and reduced those of Bacteroidales, Lachnospiraceae, Rikenellaceae, and Desulfovibrio. In addition, it reduced inflammation, inhibiting the overexpression of TLR4 and p\u2010JNK and increasing the expression of PI3K, GLUT2, and other proteins, which are closely related to oxidative stress, thereby promoting the metabolism of glucose.<\/jats:p>","DOI":"10.1155\/2018\/8930374","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T23:31:26Z","timestamp":1545262286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0209-0615","authenticated-orcid":false,"given":"Hong-Xin","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Nan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Wan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5978-2148","authenticated-orcid":false,"given":"Ke","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02188.x"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-9032"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep20032"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25102"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15034158"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00233"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18646"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v25.22857"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35405"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep04828"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.04.005"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.09.031"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9632-z"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.033936"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-088504-9.00456-6"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jctb.1590"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.2478\/s11696-013-0481-y"},{"key":"e_1_2_9_19_2","first-page":"103","article-title":"Treatment of psoriasis vulgaris","volume":"13","author":"Schweckendiek W.","year":"1959","journal-title":"Medizinische Monatsschrift"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70121-0"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02124.x"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01619.x"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3159358"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.10.062"},{"key":"e_1_2_9_25_2","first-page":"763","article-title":"Research progress on the mechanism of berberine hypoglycemic action","volume":"44","author":"Ding Y. 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