{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:06:28Z","timestamp":1778864788977,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"vor","delay-in-days":206,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Quinone derivatives like 2\u2010(4\u2010hydroxyphenyl) amino\u20101,4\u2010naphthoquinone (Q7) are used as antitumor agents usually associated with adverse effects on the cardiovascular system. The objective of this study was to evaluate the cardioprotective effect of ascorbate on Q7\u2010induced cardiovascular response in Wistar rats. In this study, blood pressure, vascular reactivity, and intracellular calcium fluxes were evaluated in cardiomyocytes and the rat aorta. We also measured oxidative stress through lipid peroxidation (TBARS), superoxide dismutase\u2010 (SOD\u2010) like activity, and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> generation. Oral treatment of rats with ascorbate (500\u2009mg\/kg) for 20 days significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) reduced the Q7\u2010induced increase (10\u2009mg\/kg) in blood pressure and heart rate. The preincubation with ascorbate (2\u2009mM) significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) attenuated the irregular beating of the atrium induced by Q7 (10<jats:sup>\u22125<\/jats:sup>\u2009M). In addition, ascorbate induced endothelial vasodilation in the presence of Q7 in the intact aortic rings of a rat and reduced the cytosolic calcium levels in vascular smooth muscle cells. Ascorbate also reduced the Q7\u2010induced oxidative stress <jats:italic>in vivo<\/jats:italic>. Ascorbate also attenuated Q7\u2010induced SOD\u2010like activity and increased TBARS levels. These results suggest a cardioprotective effect <jats:italic>in vivo<\/jats:italic> of ascorbate in animals treated orally with a naphthoquinone derivative by a mechanism involving oxidative stress.<\/jats:p>","DOI":"10.1155\/2018\/8989676","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T23:32:55Z","timestamp":1532647975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2\u2010(4\u2010Hydroxyphenyl) Amino\u20101,4\u2010naphthoquinone in Rats"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-9295","authenticated-orcid":false,"given":"Javier","family":"Palacios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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