{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:40:45Z","timestamp":1787665245219,"version":"build-2736575974"},"reference-count":118,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:p>Head and neck squamous cell cancer (HNSCC) represents a significant burden worldwide. Chemoprevention of HNSCC is a means of cancer control with a use of drugs or natural agents in order to hinder or delay the cancer development. The purpose of this article is to review mechanism of action of different chemopreventive agents\u2019 groups and results of most important researches concerning them. The safety issues of HNSCC chemoprevention are also discussed. In case of HNSCC there is currently no agent, which would give positive result in the third phase of clinical trials. Promising results of preclinical trials are not always confirmed by further tests. Main problems are low effectiveness, high toxicity, and lack of highly specificity biomarkers for monitoring the research. New trials concerning many agents, as well as novel technologies for provision of pharmaceutical forms of them, including drug nanocarriers, are currently underway, which gives hope for finding the perfect chemopreventive agent formula.<\/jats:p>","DOI":"10.1155\/2018\/9051854","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T23:33:33Z","timestamp":1537918413000},"page":"1-15","source":"Crossref","is-referenced-by-count":15,"title":["Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-0947","authenticated-orcid":true,"given":"Krzysztof","family":"Siemianowicz","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-6102","authenticated-orcid":true,"given":"Wirginia","family":"Likus","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Health Sciences in Katowice, Medical University of Silesia, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Dorecka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Ceglana 35 Str., 40-952 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Wilk","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Health Sciences in Katowice, Medical University of Silesia, Medyk\u00f3w 18 Str., 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142odzimierz","family":"Dziubdziela","sequence":"additional","affiliation":[{"name":"Outpatient Clinic for Treatment of Chronic Pain, Wyszy\u0144skiego 12 Str., 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Markowski","sequence":"additional","affiliation":[{"name":"Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, Francuska 20\/24 Str., 40-027 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13148-017-0424-5","volume":"9","year":"2017","journal-title":"Clinical Epigenetics"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-017-0185-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.12.027"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i8.452"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1158\/1055-9965.EPI-08-0347","volume":"18","year":"2009","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.02.003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/603740"},{"issue":"2","key":"11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/19424396.2016.12220976","volume":"44","year":"2016","journal-title":"J Calif Dent Assoc"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2016-0168"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0091"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400105"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21131"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32835091bd"},{"issue":"7","key":"17","first-page":"1520","volume":"26","year":"1966","journal-title":"Cancer Research"},{"issue":"7","key":"18","first-page":"2699","volume":"36","year":"1976","journal-title":"Cancer Research"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60265-1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.10.1083"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1955.42"},{"issue":"5","key":"22","first-page":"1661","volume":"39","year":"1979","journal-title":"Cancer Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13625"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-017-1377-z"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.9.8801176"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612113152401"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-1955(97)00010-9"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009203231205"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.17.1850"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S0084-3873(08)70098-1"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30920"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.12.977"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26463"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00310-6"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/424161"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-07-0003"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4024"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1020-3"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.2174\/1389450053765879"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.024"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053422"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70311-0"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802656"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7447"},{"issue":"8","key":"45","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1470-2045(13)70181-5","volume":"14","year":"2013","journal-title":"The Lancet Oncology"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70034-1"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0249"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.4364"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0135"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0215"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01448.x"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/845340"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3192"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4645"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji095"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22042"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg448"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200900319"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.21101\/cejph.a3886"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.049"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.06.048"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/902716"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25035"},{"issue":"4b","key":"64","first-page":"2895","volume":"21","year":"2001","journal-title":"Anticancer Research"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.52.251"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-05-0301"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1997.0242"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520130109"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0131"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2013.12.005"},{"issue":"2","key":"71","first-page":"381","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/540148"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.6.1830"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0121"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-017-2515-2"},{"issue":"12","key":"76","first-page":"4174","volume":"7","year":"2001","journal-title":"Clinical Cancer Research"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.16.2.333"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC340102"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.03.043"},{"issue":"12","key":"80","first-page":"4684","volume":"6","year":"2000","journal-title":"Clinical Cancer Research"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0004"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1007\/128_2012_339"},{"key":"83","year":"2017","journal-title":"Journal of Cell Communication and Signaling"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7763"},{"issue":"11","key":"85","first-page":"4757","volume":"33","year":"2013","journal-title":"Anticancer Research"},{"key":"86","first-page":"4005","year":"2002","journal-title":"Anticancer Research"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.09.005"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01325"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0187"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3159"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.12.3010"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.4.304"},{"issue":"12","key":"93","first-page":"1770","volume":"2","year":"2001","journal-title":"Current Opinion in Infectious Diseases"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.544"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1104"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-1955(96)00010-3"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29156"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217706952"},{"issue":"2","key":"99","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/19424396.2016.12220978","volume":"44","year":"2016","journal-title":"Journal of the California Dental Association"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.2478\/v10007-012-0032-z"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.07.017"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.06.016"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/824746"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600035"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12811"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1038\/srep41573"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs209"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0006"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318183a396"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1515\/acph-2016-0039"},{"issue":"10","key":"111","first-page":"1559","volume":"29","year":"1988","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.2.105"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.2.275"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-008-9132-y"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20101031-17"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199243040-00010"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.124"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.19772"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/9051854.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/9051854.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2018\/9051854.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:29:24Z","timestamp":1693913364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2018\/9051854\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":118,"alternative-id":["9051854","9051854"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9051854","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]}}}