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During the hospital stay, she developed pneumonia and septic shock requiring norepinephrine and vasopressin. She underwent continuous venovenous hemodiafiltration. Leucovorin, filgrastim, and multiple packed red blood cell and platelet transfusions were given. She remained hypotensive and pancytopenic despite all interventions. She died on day 6 of hospital stay from acute hypoxic respiratory failure due to septic shock.<\/jats:p>","DOI":"10.1155\/2018\/9056086","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T19:45:41Z","timestamp":1528919141000},"page":"1-4","source":"Crossref","is-referenced-by-count":20,"title":["A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-4664","authenticated-orcid":true,"given":"Nasreen","family":"Shaikh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sardar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-3246","authenticated-orcid":true,"given":"Rishi","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punit","family":"Jariwala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"43","volume":"34","year":"1995","journal-title":"British Journal of Rheumatology"},{"issue":"4","key":"2","first-page":"639","volume":"20","year":"1993","journal-title":"Journal of Rheumatology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0164"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s002960000087"},{"key":"5","first-page":"218","volume":"22","year":"1995","journal-title":"Journal of Rheumatology"},{"issue":"5","key":"6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/rheumatology\/35.5.453","volume":"35","year":"1996","journal-title":"British Journal of Rheumatology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.2.110"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem370"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22783"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.027"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2014.03.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1a052"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154744"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/bf02208152"},{"issue":"1","key":"15","first-page":"16","volume":"37","year":"1997","journal-title":"Ryumachi"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/946716"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/mjt.0000000000000486"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1177\/1078155215610914"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.1.111"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.S30135"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2018\/9056086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2018\/9056086.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2018\/9056086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T19:45:43Z","timestamp":1528919143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2018\/9056086\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":20,"alternative-id":["9056086","9056086"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9056086","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]}}}