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However, whether Andro treatment could retard the progress of diabetic cardiomyopathy (DCM) remains unknown. In this study, we evaluated the effects of Andro against diabetes\u2010induced myocardial dysfunction and explored the underlying mechanism in STZ\u2010induced diabetic mice. As a result, treatment with Andro dose dependently suppressed cardiac inflammation and oxidative stress, accompanied by decreasing cardiac apoptosis, which subsequently ameliorated cardiac fibrosis and cardiac hypertrophy. Further, Andro blocked hyperglycemia\u2010triggered reactive oxygen species (ROS) generation by suppressing NADPH oxidase (NOX) activation and augmenting nuclear factor erythroid 2\u2010related factor 2 (Nrf2) expression both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Our results suggest that the cardioprotective effects afforded by Andro treatment involve the modulation of NOX\/Nrf2\u2010mediated oxidative stress and NF\u2010<jats:italic>\u03ba<\/jats:italic>B\u2010mediated inflammation. The present study unravels the therapeutic potential of Andro in the treatment of DCM by attenuating oxidative stress, inflammation, and apoptosis.<\/jats:p>","DOI":"10.1155\/2018\/9086747","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T23:32:54Z","timestamp":1529969574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF\u2010<i>\u03ba<\/i>B\u2010Mediated Inflammation"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-1353","authenticated-orcid":false,"given":"Ershun","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-3502","authenticated-orcid":false,"given":"Yuxia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1054"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.6.1414"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.710830"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61402-1"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1092015"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.06.030"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7415"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8343"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.02.011"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1577"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.07.025"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx011"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.033"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03675-z"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04673-x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2017.08.009"},{"key":"e_1_2_9_17_2","first-page":"255","article-title":"Andrographolide and analogues in cancer prevention","volume":"7","author":"Mishra S. 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