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The traditional Chinese medicine formula Jiu Wei Zhen Xin Granula (JWZXG) is prescribed to treat generalized anxiety disorder (GAD) in China. This study was to assess the efficacy and safety of JWZXG in patients with GAD. <jats:italic>Method<\/jats:italic>. Data were pooled from 14 randomized controlled trials involving the assessment of mean changes of Hamilton Anxiety Rating Scale (HAMA) total scores, response rates, adverse event rates, quality, publication bias, and risk of bias. <jats:italic>Results<\/jats:italic>. Pooled analysis showed no significant difference in response rate (risk ratio 1.01, 95% CI [0.93\u20131.08]; <jats:italic>Z<\/jats:italic> test = 0.17, <jats:italic>P<\/jats:italic> = 0.86) and no significant difference between JWZXG group and azapirones group (RR 0.69, 95% CI [0.45, 1.06]; <jats:italic>Z<\/jats:italic> test = 1.69, <jats:italic>P<\/jats:italic> = 0.09) in rate of adverse events. Though no difference exists between JWZXG group and azapirones group in HAMA total score from baseline, JWZXG group was inferior to selective serotonin reuptake inhibitors (SSRIs) group (WMD \u22120.93, 95% CI [\u22121.64, \u22120.23]; <jats:italic>Z<\/jats:italic> test = 2.6, <jats:italic>P<\/jats:italic> = 0.009) which had more adverse events than JWZXG group (RR 0.64, 95% CI [0.46, 0.89]; <jats:italic>Z<\/jats:italic> test = 2.63, <jats:italic>P<\/jats:italic> = 0.009). <jats:italic>Conclusions<\/jats:italic>. This meta\u2010analysis preliminarily suggests that JWZXG is as effective as azapirones, though having the same possibility of suffering AEs. JWZXG was inferior to SSRIs but causes fewer AEs in the treatment of GAD.<\/jats:p>","DOI":"10.1155\/2018\/9090181","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T23:34:45Z","timestamp":1520465685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of a Formulated Herbal Granula, Jiu Wei Zhen Xin, for Generalized Anxiety Disorder: A Meta\u2010Analysis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Sheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-6538","authenticated-orcid":false,"given":"Lin-lin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-8559","authenticated-orcid":false,"given":"Xin-jian","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-533X","authenticated-orcid":false,"given":"Jie-kun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sui-yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-3425","authenticated-orcid":false,"given":"Hui-yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.617"},{"key":"e_1_2_10_3_2","first-page":"21","article-title":"Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project","volume":"420","author":"Alonso J.","year":"2005","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.10065"},{"key":"e_1_2_10_5_2","first-page":"17","article-title":"Prevalence and correlates of GAD in primary care","volume":"143","author":"Wittchen H.","year":"2001","journal-title":"Fortschritte der Medizin. 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