{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:59:26Z","timestamp":1790891966395,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin University and Jilin Province","award":["SXGJSF2017-1"],"award-info":[{"award-number":["SXGJSF2017-1"]}]},{"name":"Jilin University and Jilin Province","award":["20160204029YY"],"award-info":[{"award-number":["20160204029YY"]}]},{"name":"Jilin University and Jilin Province","award":["20150203002NY"],"award-info":[{"award-number":["20150203002NY"]}]},{"name":"Science and Technology Key Project in Jilin Province of China","award":["SXGJSF2017-1"],"award-info":[{"award-number":["SXGJSF2017-1"]}]},{"name":"Science and Technology Key Project in Jilin Province of China","award":["20160204029YY"],"award-info":[{"award-number":["20160204029YY"]}]},{"name":"Science and Technology Key Project in Jilin Province of China","award":["20150203002NY"],"award-info":[{"award-number":["20150203002NY"]}]},{"name":"Science and Technology Key Project in Jilin Province of China","award":["SXGJSF2017-1"],"award-info":[{"award-number":["SXGJSF2017-1"]}]},{"name":"Science and Technology Key Project in Jilin Province of China","award":["20160204029YY"],"award-info":[{"award-number":["20160204029YY"]}]},{"name":"Science and Technology Key Project in Jilin Province of China","award":["20150203002NY"],"award-info":[{"award-number":["20150203002NY"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    <jats:italic>Sarcodon imbricatus<\/jats:italic>\n                    (SI), a precious edible fungus, contains 35.22% of total sugar, 18.33% of total protein, 24 types of fatty acid, 16 types of amino acid, and 8 types of minerals. Encouragingly, it is rich in potential antioxidants such as total polyphenols (0.41%), total sterols (3.16%), and vitamins (0.44%). In the present study, the antifatigue properties of SI and its potential mechanisms of action were explored by the experiments on acute excise\u2010treated mice and chronic fatigue syndrome (CFS) mice. SI (0.25, 0.5, and 1\u2009g\/kg) significantly enhanced exercise tolerance in the weight\u2010loaded forced swimming test (FST) and rota\u2010rod test (RRT) and reduced the immobility in the tail suspension test on CFS mice. SI markedly increased the levels of glycogen in the liver and adenosine triphosphate (ATP) in the liver and muscle and decreased the lactic acid (LD) and blood urea nitrogen (BUN) content in both acute swimming\u2010treated mice and CFS mice. SI improved the endogenous cellular antioxidant enzyme contents in the two mouse models by improving the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH\u2010Px) and reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels in serum, liver, and muscle, respectively. In CFS mice, the enhanced expression levels of nuclear factor erythroid\u20102\u2010related factor 2 (Nrf2), SOD1, SOD2, heme oxygenase\u20101 (HO\u20101), and catalase (CAT) in the liver were observed after a 32\u2010day SI administration. Our data indicated that SI possessed antifatigue activity, which may be related to its ability to normalize energy metabolism and Nrf2\u2010mediated oxidative stress. Consequently, SI can be expected to serve as a novel natural antifatigue supplement in health foods.\n                  <\/jats:p>","DOI":"10.1155\/2018\/9140896","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T19:43:37Z","timestamp":1530215017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Antifatigue Potential Activity of\n                    <i>Sarcodon imbricatus<\/i>\n                    in Acute Excise\u2010Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2\u2010Mediated Oxidative Stress"],"prefix":"10.1155","volume":"2018","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zepeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-877X","authenticated-orcid":false,"given":"Lirong","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-4174","authenticated-orcid":false,"given":"Di","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3517824"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0078-y"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000341"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(96)00015-8"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.03.004"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.05.021"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00151-3"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00745.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9975-2"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.04.019"},{"key":"e_1_2_8_11_2","first-page":"741","article-title":"Chronic fatigue syndrome: diagnosis and treatment","volume":"86","author":"Yancey J. R.","year":"2012","journal-title":"American Family Physician"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-121259"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2014.06.004"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nen017"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.760103"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/amr.518-523.608"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0981-9428(02)01395-5"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.myc.2013.08.001"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2010.05.021"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.5586\/am.2012.006"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.5586\/am.1086"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.04.006"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.06.054"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-005-9550-5"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2013000500004"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf001525d"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/treephys\/24.10.1129"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2012.09.024"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-014-1203-8"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-017-0323-z"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4105"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.56093\/ijans.v82i10.24281"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138909"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.03.039"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.09.072"},{"key":"e_1_2_8_36_2","unstructured":"ZhaoY. Effects of exercise on the concentration of 5-HT in hippocampus and occipital cortex and peripheral Th1\/Th2 balance in rats under chronic fatigue syndrome Proceedings of the 9th China National Convention on Sports Science Vol I: Sports Psychology And Physical Health 2012 Shanghai China 359\u2013362."},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-010-0225-y"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.04.001"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-013-0076-y"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.05.001"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.10.015"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00021412"},{"key":"e_1_2_8_43_2","first-page":"321","article-title":"Anti-fatigue effects of polysaccharides extracted from Portulaca oleracea L. in mice","volume":"51","author":"Xu Z.","year":"2014","journal-title":"Indian Journal of Biochemistry & Biophysics"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8020106"},{"key":"e_1_2_8_45_2","first-page":"3948","article-title":"Preparation of oligopeptides from corn gluten meal by two enzymes at one step using response surface methodology and investigation of their antifatigue activities","volume":"28","author":"Xu T.","year":"2017","journal-title":"Biomedical Research"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0068"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.2837"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.25135\/rnp.32.17.09.051054"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pex417"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/562345"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.08.055"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.850518"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930175"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1139\/Y08-110"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00403.2009"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.6.2032"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.04.020"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01001-3"},{"key":"e_1_2_8_59_2","first-page":"143","article-title":"Evaluation of oxidative stress status following polyherbal formulation therapy in patients of cholelithiasis with choledocholithiasis","volume":"24","author":"Srivastava P.","year":"2005","journal-title":"Ancient Science of Life"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00328"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.141790"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00586.2015"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21870"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.08.003"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051618798"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2015.06.012"},{"key":"e_1_2_8_67_2","first-page":"11856","article-title":"Soyasaponins protects against physical fatigue and improves exercise performance in mice","volume":"10","author":"Xu Y.","year":"2017","journal-title":"International Journal of Clinical and Experimental Medicine"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/9140896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/9140896.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/9140896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T07:09:49Z","timestamp":1723014589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/9140896"}},"subtitle":[],"editor":[{"given":"D\u00e9bora Villa\u00f1o","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/9140896"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9140896","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9140896"}}