{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:41:15Z","timestamp":1782524475832,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:00:00Z","timestamp":1523750400000},"content-version":"vor","delay-in-days":104,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Seongnam Industry Promotion Agency\u2019s 2014 Medibio"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. The purpose of this study was to investigate whether the ingestion of alkaline\u2010reduced water (ARW) is helpful in improving the symptoms of diarrhea\u2010predominant irritable bowel syndrome (IBS). <jats:italic>Methods.<\/jats:italic> Twenty\u2010seven patients (male, 25.9%; mean, 41.7 years old) with diarrhea\u2010predominant IBS were randomly allocated to two groups. For eight weeks, the ARW group (<jats:italic>n<\/jats:italic> = 13) ingested at least 2 liters\/day of ARW, while the control group (<jats:italic>n<\/jats:italic> = 14) ingested placebo water. IBS symptom scores (quality\u2010of\u2010life, abdominal pain\/discomfort), stool form, and frequency were assessed before and after treatment via questionnaires. <jats:italic>Results.<\/jats:italic> Eight patients (61.5%) in the ARW group and six patients (42.9%) in the control group indicated that their symptoms had improved in more than four out of the eight weeks of treatment (<jats:italic>p<\/jats:italic> = 0.449). The IBS quality\u2010of\u2010life score significantly improved from 57.2 to 30.8 in the ARW group; this improvement was significantly greater than the slight improvement from 48.7 to 42.2 observed in the control group (<jats:italic>p<\/jats:italic> = 0.029). The abdominal pain score improved from 1.8 to 0.9 in the ARW group and from 1.8 to 1.1 in the control group, with no significant group difference (<jats:italic>p<\/jats:italic> = 0.232). <jats:italic>Conclusions.<\/jats:italic> Drinking ARW for eight weeks improves the quality of life in patients with diarrhea\u2010predominant IBS.<\/jats:p>","DOI":"10.1155\/2018\/9147914","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T23:32:44Z","timestamp":1523835164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Alkaline\u2010Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double\u2010Blind, Placebo\u2010Controlled Pilot Study"],"prefix":"10.1155","volume":"2018","author":[{"given":"Dong Woo","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Min","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-410X","authenticated-orcid":false,"given":"Dong Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,15]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.2147\/clep.s40245"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2014.20.2.242"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12938"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2016.07.006"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0502-z"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000161"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i10.2482"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i25.7621"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309151"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16216"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12490"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0000000000000418"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12530"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617731968"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods7020013"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1383819"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i16.2556"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.63.186"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojgas.2016.63012"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000449436"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100702"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.33.1319"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043661802002323"},{"key":"e_1_2_8_24_2","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman D. 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