{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:56:24Z","timestamp":1790855784971,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Nonhepatosplenic\/noncutaneous <jats:italic>\u03b3\u03b4<\/jats:italic> peripheral T-cell lymphoma (NHNC<jats:italic>\u03b3\u03b4<\/jats:italic> PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia\/lymphoma to NHNC<jats:italic>\u03b3\u03b4<\/jats:italic> PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Nevertheless, both of our cases involved relapse as PTCL manifested with skin involvement and an overt shift from blastic morphology to large granular leukemia-like mature T cells. Among other notable molecular characteristics, expression of immature markers such as TdT was lost in both cases. Based on cytogenetics, phenotype, and morphology, both patients represent a novel phenomenon of clonal transformation from T-ALL to PTCL which has rarely been reported in the literature. Such transformation may carry important diagnostic and biological implications.<\/jats:p>","DOI":"10.1155\/2018\/9191582","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T18:46:08Z","timestamp":1519843568000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases"],"prefix":"10.1155","volume":"2018","author":[{"given":"Michael","family":"Markow","sequence":"first","affiliation":[{"name":"Department of Pathology, Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1875-8966","authenticated-orcid":true,"given":"Abu-Sayeef","family":"Mirza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of South Florida, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Perez","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program, Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Horna","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Anasetti","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubomir","family":"Sokol","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad O.","family":"Hussaini","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"2008"},{"key":"2","first-page":"245","volume":"2","year":"1986","journal-title":"Year in Immunology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.889821"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.11.003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880815)62:4<705::aid-cncr2820620410>3.0.co;2-z"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf293"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10072"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0037-1963(03)00137-9"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.04.011"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-4608(99)00151-x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1309\/lrkx8ce7gvpcr1ft"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-166363"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2008.080054"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701784409"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.255"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12313"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-318873"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2018\/9191582.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2018\/9191582.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2018\/9191582.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T18:46:08Z","timestamp":1519843568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2018\/9191582\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":17,"alternative-id":["9191582","9191582"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9191582","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}