{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:41:04Z","timestamp":1783982464231,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. The aim of this study was to assess the incidence, the prenatal detection rate by ultrasound, and the pregnancy outcome of spina bifida (SB) in Denmark (DK) in 2008\u20132015 and to compare results to national data from Sweden.<jats:italic> Methods<\/jats:italic>. Data were retrieved from the Danish Fetal Medicine Database, which includes International Classification of Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses and pregnancy outcome. Missing data were obtained from the National Patient Register. Livebirth data with myelomeningocele (MMC) in Sweden were obtained from different databases.<jats:italic> Results<\/jats:italic>. There were 234 cases with SB in DK in 2008\u20132015. The incidence of SB was 4.9\u2009:\u200910,000; 89% were detected with ultrasound prior to week 22; 90% of these pregnancies were terminated (ToP); 91% were isolated malformations of which 11% showed abnormal karyotype. The incidence of newborns with MMC was 1.3\u2009:\u200910,000 in Sweden.<jats:italic> Conclusions<\/jats:italic>. Ultrasound screening has a major impact on the epidemiology of SB. The prenatal detection rate of SB was high, and most SB cases were isolated and had a normal karyotype. Among women with a prenatal fetal diagnosis of SB, 90% chose to have ToP. The incidence of newborns with SB was higher in Sweden than in DK.<\/jats:p>","DOI":"10.1155\/2018\/9203985","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T18:36:40Z","timestamp":1517510200000},"page":"1-8","source":"Crossref","is-referenced-by-count":27,"title":["Ultrasound in Prenatal Diagnostics and Its Impact on the Epidemiology of Spina Bifida in a National Cohort from Denmark with a Comparison to Sweden"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-3448","authenticated-orcid":true,"given":"Charlotte Rosenkrantz","family":"Bodin","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Mylius","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Aarhus University Hospital, Aarhus, 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Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Bernt","family":"Wulff","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Center for Prenatal Diagnostics, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav Bj\u00f8rn","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Center for Prenatal Diagnostics, Aarhus University Hospital, Aarhus, 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