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To date, approximately 50 genes have been implicated in PD pathogenesis, including both Mendelian genes with rare mutations and low-penetrance genes with common polymorphisms. Previous studies of low-penetrance genes focused on protein-coding genes, and less attention was given to long noncoding RNAs (lncRNAs). In this study, we aimed to investigate the susceptibility roles of lncRNA gene polymorphisms in the development of PD. Therefore, polymorphisms (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>15<\/mml:mn><\/mml:mrow><\/mml:math>) of the<jats:italic>PINK1-AS<\/jats:italic>,<jats:italic>UCHL1-AS<\/jats:italic>,<jats:italic>BCYRN1<\/jats:italic>,<jats:italic>SOX2-OT<\/jats:italic>,<jats:italic>ANRIL<\/jats:italic>and<jats:italic>HAR1A<\/jats:italic>lncRNAs genes were genotyped in Hungarian PD patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>160<\/mml:mn><\/mml:mrow><\/mml:math>) and age- and sex-matched controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>167<\/mml:mn><\/mml:mrow><\/mml:math>). The rare allele of the rs13388259 intergenic polymorphism, located downstream of the<jats:italic>BCYRN1<\/jats:italic>gene, was significantly more frequent among PD patients than control individuals (OR\u2009=\u20092.31;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0015<\/mml:mn><\/mml:mrow><\/mml:math>). In silico prediction suggested that this polymorphism is located in a noncoding region close to the binding site of the transcription factor HNF4A, which is a central regulatory hub gene that has been shown to be upregulated in the peripheral blood of PD patients. The rs13388259 polymorphism may interfere with the binding affinity of transcription factor HNF4A, potentially resulting in abnormal expression of target genes, such as<jats:italic>BCYRN1<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2018\/9351598","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T23:31:08Z","timestamp":1522798268000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["The rs13388259 Intergenic Polymorphism in the Genomic Context of the<i>BCYRN1<\/i>Gene Is Associated with Parkinson\u2019s Disease in the Hungarian Population"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-8456","authenticated-orcid":true,"given":"S\u00e1ndor","family":"M\u00e1rki","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, University of Szeged, Somogyi u. 4, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-8940","authenticated-orcid":true,"given":"Anik\u00f3","family":"G\u00f6bl\u00f6s","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, Kor\u00e1nyi fasor 6, 6720 Szeged, Hungary"},{"name":"MTA-SZTE Dermatological Research Group, University of Szeged, Kor\u00e1nyi fasor 6, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Szl\u00e1vicz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, Kor\u00e1nyi fasor 6, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7556-9600","authenticated-orcid":true,"given":"N\u00f3ra","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Szeged, Semmelweis u. 6, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Balicza","sequence":"additional","affiliation":[{"name":"Institute of Genomic Medicine and Rare Disorders, Semmelweis University, T\u00f6m\u0151 u. 25-29, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bereznai","sequence":"additional","affiliation":[{"name":"Institute of Genomic Medicine and Rare Disorders, Semmelweis University, T\u00f6m\u0151 u. 25-29, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annam\u00e1ria","family":"Tak\u00e1ts","sequence":"additional","affiliation":[{"name":"Department of Neurology, Semmelweis University, VIII. 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