{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:25:30Z","timestamp":1767889530584,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clermont-Ferrand University Hospital","award":["AOI 2015"],"award-info":[{"award-number":["AOI 2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2018,6,13]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. In a context of inflammatory disease such as juvenile idiopathic arthritis (JIA), we do not know what impact physical activity may have on a deregulated immune system. The objective is to measure the impact of a single bout of exercise on plasma inflammatory markers such as calprotectin, IL-6, sIL-6R, sgp130, and the hypothalamic-pituitary-adrenal axis in children with juvenile idiopathic arthritis. <jats:italic>Methods<\/jats:italic>. Twelve children with JIA performed a nonexercise control day and a consecutive day that included a 20\u2009min exercise bout at 70% of max-HR at 08:30\u2009am. Venous blood samples were taken at 08:30, 08:50, 09:30, 10:30\u2009am, and 12:00\u2009pm to measure plasma concentrations of calprotectin, IL-6, sIL-6R, sgp130, cortisol, and ACTH. Pain was evaluated at 08:30, 08:50\u2009am, and 06:00\u2009pm. <jats:italic>Results<\/jats:italic>. There was a transient twofold increase in postexercise self-evaluated pain (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:math>) that disappeared in the evening. A single bout of exercise resulted in a 1.7-fold increase in plasma calprotectin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) but not IL-6 and its soluble receptors. Calprotectin levels returned to baseline within 3 hours after cessation of exercise. <jats:italic>Conclusion<\/jats:italic>. Acute exercise in children with JIA induced slightly musculoskeletal leg pain and transient increased plasma calprotectin levels but not IL-6 levels. Trial registration in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>, reference number NCT 02502539, registered on 29 May 2015.<\/jats:p>","DOI":"10.1155\/2018\/9365745","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T19:47:34Z","timestamp":1528919254000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5180-9916","authenticated-orcid":true,"given":"Rochette","family":"Emmanuelle","sequence":"first","affiliation":[{"name":"P\u00e9diatrie G\u00e9n\u00e9rale Multidisciplinaire, H\u00f4pital Estaing, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France"},{"name":"Universit\u00e9 Clermont Auvergne, INSERM, CIC 1405, Unit\u00e9 CRECHE, 63000 Clermont-Ferrand, France"},{"name":"Laboratoire des Adaptations M\u00e9taboliques en conditions Physiologiques et Physiopathologiques (AME2P), Universit\u00e9 Clermont Auvergne, EA 3533, Clermont-Ferrand, France"},{"name":"CRNH-Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duch\u00e9","family":"Pascale","sequence":"additional","affiliation":[{"name":"Laboratoire des Adaptations M\u00e9taboliques en conditions Physiologiques et Physiopathologiques (AME2P), Universit\u00e9 Clermont Auvergne, EA 3533, Clermont-Ferrand, France"},{"name":"CRNH-Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hourd\u00e9","family":"Christophe","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (E A7424), Universit\u00e9 Savoie Mont Blanc, 73376 Le Bourget-du-Lac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evrard","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, INRA, UMR 1019 UNH, ECREIN, 63000 Clermont-Ferrand, France"},{"name":"Service d\u2019Immunologie, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pereira","family":"Bruno","sequence":"additional","affiliation":[{"name":"CHU Clermont-Ferrand, D\u00e9l\u00e9gation de la Recherche Clinique et Innovations, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Echaubard","family":"St\u00e9phane","sequence":"additional","affiliation":[{"name":"P\u00e9diatrie G\u00e9n\u00e9rale Multidisciplinaire, H\u00f4pital Estaing, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, 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