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We present an unusually challenging patient who presented with clinical symptoms involving cranial nerves VII and VIII and a parotid-region mass, which was S100-positive while lacking in melanocytic pigment and markers. Over a year after resection of the parotid mass, both a cutaneous primary lentigo maligna melanoma and a metastatic CP angle melanoma were diagnosed in the same patient, prompting reconsideration of the diagnosis in the original parotid-region mass. Next-generation sequencing of a panel of cancer-associated genes demonstrated 19 identical, clinically significant mutations as well as a high tumor mutation burden in both the parotid-region and CP angle tumors, indicating a metastatic relationship between the two and a melanocytic identity of the parotid-region tumor.<\/jats:p>","DOI":"10.1155\/2018\/9410465","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T19:44:43Z","timestamp":1530215083000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Melanoma Mimicking Malignant Peripheral Nerve Sheath Tumor with Spread to the Cerebellopontine Angle: Utility of Next-Generation Sequencing in Diagnosis"],"prefix":"10.1155","volume":"2018","author":[{"given":"Katie","family":"Fox Hanson","sequence":"first","affiliation":[{"name":"Department of Pathology, Saint Louis University School of Medicine, 1402 S. 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