{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:59:44Z","timestamp":1759010384189,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Rotavirus<\/jats:italic> is a double-stranded RNA virus belonging to the family of <jats:italic>Reoviridae<\/jats:italic>. The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6\u201310% of the population. Clinical manifestations include gastrointestinal and\/or extraintestinal symptoms which recede with gluten withdrawal. The pathogenesis of the disease is still unknown. Aim of this work is to clarify some aspects of its pathogenesis using a gene array approach. Our results suggest that NCGS may have an autoimmune origin. This is based both on gene expression data (i.e., TH17-interferon signatures) and on the presence of TH17 cells and of serological markers of autoimmunity in NCGS. Our results also indicate a possible involvement of <jats:italic>rotavirus<\/jats:italic> infection in the pathogenesis of nonceliac gluten sensitivity similarly to what we have previously shown in celiac disease.<\/jats:p>","DOI":"10.1155\/2018\/9419204","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T19:32:23Z","timestamp":1521142343000},"page":"1-26","source":"Crossref","is-referenced-by-count":6,"title":["Immune Response to <i>Rotavirus<\/i> and Gluten Sensitivity"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-5698","authenticated-orcid":true,"given":"Antonio","family":"Puccetti","sequence":"first","affiliation":[{"name":"Immunology Area, Pediatric Hospital Bambino Ges\u00f9, Viale San Paolo 15, 00146 Rome, Italy"},{"name":"Department of Experimental Medicine, Section of Histology, University of Genova, Via G.B. 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