{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:31:57Z","timestamp":1740177117028,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570554","81501566","150162"],"award-info":[{"award-number":["81570554","81501566","150162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570554","81501566","150162"],"award-info":[{"award-number":["81570554","81501566","150162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Family Planning Commission of Sichuan Province","award":["81570554","81501566","150162"],"award-info":[{"award-number":["81570554","81501566","150162"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Background and Aim.<\/jats:italic> The outcome of cirrhotic patients with main portal vein occlusion and portal cavernoma after the first episode of acute variceal bleeding (AVB) is unknown. We compared short-term outcomes after AVB in cirrhotic patients with and without portal cavernoma.<jats:italic> Methods.<\/jats:italic> Between January 2009 and September 2014, 28 patients with cirrhosis and portal cavernoma presenting with the first occurrence of AVB and 56 age-, sex-, and Child-Pugh score-matched cirrhotic patients without portal cavernoma were included. The primary endpoints were 5-day treatment failure and 6-week mortality.<jats:italic> Results.<\/jats:italic> The 5-day treatment failure rate was higher in the cavernoma group than in the control group (32.1% versus 12.5%; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.031<\/mml:mn><\/mml:math>). The 6-week mortality rate did not differ between the cavernoma and control group (25% versus 12.5%, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.137<\/mml:mn><\/mml:math>). Multivariable Cox proportional hazard regression analyses revealed that 5-day treatment failure (HR = 1.223, 95% CI = 1.082 to 1.384; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) independently predicted 6-week mortality.<jats:italic> Conclusions.<\/jats:italic> Cirrhotic patients with AVB and portal cavernoma have worse short-term prognosis than patients without portal cavernoma. The 5-day treatment failure was an independent risk factor for 6-week mortality in patients with cirrhosis and portal cavernoma.<\/jats:p>","DOI":"10.1155\/2018\/9491856","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T18:30:54Z","timestamp":1516818654000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding"],"prefix":"10.1155","volume":"2018","author":[{"given":"Xuefeng","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoze","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-7258","authenticated-orcid":true,"given":"Jinlin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-9342","authenticated-orcid":true,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309262"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50385"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra0901512"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70455-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9236-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.034"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04182.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22772"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.01.038"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0b013e31826e8e53"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.313"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0910102"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840400408"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112236"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.452"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27546"}],"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2018\/9491856.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2018\/9491856.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2018\/9491856.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T18:31:00Z","timestamp":1516818660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjgh\/2018\/9491856\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":17,"alternative-id":["9491856","9491856"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9491856","relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"type":"print","value":"2291-2789"},{"type":"electronic","value":"2291-2797"}],"subject":[],"published":{"date-parts":[[2018]]}}}