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Galectin-9 (Gal-9) may modulate a variety of biologic functions and play an important role in Th1\/Th2 immune deviation. To analyze the mechanism of Gal-9 in abortion, we used the classical abortion-prone mouse model (DBA\/2-mated CBA\/J mice) to detect the expression of Gal-9 at the maternal-fetal interface. We also mimicked the immune environment of pregnancy by culturing trophoblast cells with peripheral blood mononuclear cells (PBMCs) to explore how Gal-9 might be involved in the pathogenesis of abortion. We found that the expression levels of Gal-9 in abortion-prone matings were lower than that for controls. Using a coculture system, we detected a Th1 preponderance in the coculture from abortion-prone matings. Furthermore, Gal-9 blockade augmented the imbalance of Th1\/Th2 immunity in abortion-prone matings by promoting the secretion of Th1-derived cytokines in coculture, while there was a Th2 preponderance when we administered recombinant Gal-9. In conclusion, our results suggest that the Gal-9 signal is important for the regulation of PBMC function toward a Th2 bias at the maternal-fetal interface, which is beneficial for the maintenance of a normal pregnancy.<\/jats:p>","DOI":"10.1155\/2018\/9517842","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T18:37:41Z","timestamp":1517423861000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["Impaired Gal-9 Dysregulates the PBMC-Induced Th1\/Th2 Imbalance in Abortion-Prone Matings"],"prefix":"10.1155","volume":"2018","author":[{"given":"Mengzhou","family":"He","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, 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