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The endometrial implant was found at the hepatic flexure, an exceedingly rare location for endometriosis invasion with no cases distinctly reported in the literature. Additionally, the presentation of gastrointestinal endometriosis as iron deficiency anemia is not well documented in the literature. Instead of surgery, we prescribed a novel medical therapeutic approach using conjugated estrogen-bazedoxifene to antagonize the proliferative effects of estrogen on endometrial tissue. After five months of therapy and repeat colonoscopy, no evidence of endometrial tissue remained in the hepatic flexure.<\/jats:p>","DOI":"10.1155\/2018\/9587536","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T18:42:03Z","timestamp":1518633723000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Postmenopausal Deep Infiltrating Endometriosis of the Colon: Rare Location and Novel Medical Therapy"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7338-7213","authenticated-orcid":true,"given":"Benjamin M.","family":"Snyder","sequence":"first","affiliation":[{"name":"University of South Carolina School of Medicine Greenville, Greenville, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Beets","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\/Liver Center, Greenville Health System, University of South Carolina School of Medicine Greenville, Greenville, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Lessey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Greenville Health System, University of South Carolina School of Medicine Greenville, Greenville, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R. 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