{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:53:24Z","timestamp":1784375604513,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2018,7,2]]},"abstract":"<jats:p>Acute coronary syndrome (ACS) describes any condition characterized by myocardial ischaemia and reduction in blood flow. The physiopathological process of ACS is the atherosclerosis where MIF operates as a major regulator of inflammation. The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG). All samples were run using the conditions indicated in TaqMan Gene Expression Assay protocol. Determination of MIF serum levels were performed by enzyme-linked immunosorbent assay and MIF ELISA Kit. ST-segment elevation myocardial infraction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) showed 0.8 and 0.88, respectively, less expression of <jats:italic>MIF<\/jats:italic> mRNA with regard to CG. UA and STEMI presented more expression than NSTEMI 5.23 and 0.68, respectively. Otherwise, ACS patients showed significant higher MIF serum levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:mrow><\/mml:math>) compared with CG. Furthermore, the highest soluble levels of MIF were presented by STEMI (11.21\u2009ng\/dL), followed by UA (10.34\u2009ng\/dL) and finally NSTEMI patients (8.75\u2009ng\/dL); however, the differences were not significant. These novel observations further establish the process of MIF release after cardiovascular events and could support the idea of MIF as a new cardiac biomarker in ACS.<\/jats:p>","DOI":"10.1155\/2018\/9635652","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T20:53:29Z","timestamp":1530564809000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["<i>MIF<\/i> mRNA Expression and Soluble Levels in Acute Coronary Syndrome"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-9203","authenticated-orcid":true,"given":"Emmanuel","family":"Vald\u00e9s-Alvarado","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-022X","authenticated-orcid":true,"given":"Yeminia","family":"Valle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-9260","authenticated-orcid":true,"given":"Jos\u00e9 Francisco","family":"Mu\u00f1oz-Valle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4814-9934","authenticated-orcid":true,"given":"Ilian Janet","family":"Garc\u00eda-Gonzalez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Valdez-Haro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"},{"name":"Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector Enrique","family":"Flores-Salinas","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional de Occidente (CMNO), IMSS, Independencia Oriente, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Manuel","family":"P\u00e9rez-Ibarra","sequence":"additional","affiliation":[{"name":"Especialidad de Cardiolog\u00eda, Centro M\u00e9dico Nacional de Occidente (CMNO), IMSS, Independencia Oriente, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-929X","authenticated-orcid":true,"given":"Elena","family":"Sandoval-Pinto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-2797","authenticated-orcid":true,"given":"Jorge Ram\u00f3n","family":"Padilla-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4065\/84.10.917"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31824e18c2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1606915"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.06.33"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.acmx.2015.04.001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3578"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu281"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.28808"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-05-0341"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-012-0378-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.217877"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2016.04.002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn120"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22509"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038376"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.12.013"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1951-6"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130828"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.01.015"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu071"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01041.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/HPC.0b013e3182846e16"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.83"},{"key":"24","first-page":"71","volume":"3","year":"2013","journal-title":"Biostatistics, Bioinformatics and Biomathematics"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.65240"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007351"},{"key":"27","first-page":"297","volume":"153","year":"2017","journal-title":"Gaceta Medica De Mexico"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-017-0880-8"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.12.032"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/704854"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00115"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2015(03)03"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/315174"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00373"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.113.000226"}],"container-title":["Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2018\/9635652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2018\/9635652.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2018\/9635652.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T20:53:32Z","timestamp":1530564812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crp\/2018\/9635652\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,2]]},"references-count":35,"alternative-id":["9635652","9635652"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9635652","relation":{},"ISSN":["2090-8016","2090-0597"],"issn-type":[{"value":"2090-8016","type":"print"},{"value":"2090-0597","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,2]]}}}