{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:23:42Z","timestamp":1792801422722,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2018,7,9]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic>To determine the prevalence of weight loss (WL) in PD patients, its relationship to the severity of motor manifestations and appetite changes.<jats:italic>Methods.<\/jats:italic>144 PD patients and 120 controls were evaluated in a single session. All subjects were asked about changes in body weight and appetite. PD patients were examined with the UPDRS-III and the Hoehn and Yahr (HY) scales. Subscores of tremor, bradykinesia \/rigidity, and non-dopaminergic symptoms (NDS) were analyzed individually. Multivariable logistic regression analysis was used to determine an association between WL and PD motor manifestations.<jats:italic>Results.<\/jats:italic>48.6 % of PD patients presented WL compared to 20.8 % of controls (p &lt; 0.001). Weight losers were significantly older and had longer disease duration, higher scores in HY stages, UPDRS-III, and NDS-subscore. Multivariable logistic regression analysis demonstrated that WL was associated with NDS-subscore (p= 0.002; OR: 1.33) and older age (p= 0.037; OR: 1.05). Appetite in PD cases losing weight was unchanged (35.7 %), decreased (31.4 %), or even increased (32.9).<jats:italic>Conclusions.<\/jats:italic>Our results showed that WL occurs in almost half of PD patients and it is largely the consequence of disease progression rather than involuntary movements or a decrease in food intake.<\/jats:p>","DOI":"10.1155\/2018\/9642524","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T19:34:58Z","timestamp":1531164898000},"page":"1-6","source":"Crossref","is-referenced-by-count":48,"title":["Weight Loss in Parkinson\u2019s Disease: The Relationship with Motor Symptoms and Disease Progression"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-0806","authenticated-orcid":true,"given":"Maria G.","family":"Cersosimo","sequence":"first","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Disorders Unit, Hospital de Clinicas, University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela B.","family":"Raina","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Disorders Unit, Hospital de Clinicas, University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Pellene","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Disorders Unit, Hospital de Clinicas, University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico E.","family":"Micheli","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Disorders Unit, Hospital de Clinicas, University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1695-3397","authenticated-orcid":true,"given":"Cristian R.","family":"Calandra","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Disorders Unit, Hospital de Clinicas, University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Maiola","sequence":"additional","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Disorders Unit, Hospital de Clinicas, University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10577"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1165"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00307.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21068"},{"issue":"19","key":"5","first-page":"1505","volume":"71","year":"2008","journal-title":"Neurology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.2.650s"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199204000-00005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01818955"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(95)00269-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1993.tb01895.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/BF02251202"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1042\/cs0830199"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.88"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6763.1256"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22372"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02617.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00364.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"issue":"4","key":"20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0749-0690(18)30146-0","volume":"13","year":"1997","journal-title":"Clinics in Geriatric Medicine"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-5-568"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00771.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"24","first-page":"153","volume-title":"UPDRS development committee. 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