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Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is involved in many physiological and pathological processes in mammals. However, the effect and mechanism of H<jats:sub>2<\/jats:sub>S in diaphragm dysfunction have not been fully elucidated. In this study, we detected that the level of H<jats:sub>2<\/jats:sub>S was decreased in lipopolysaccharide\u2010 (LPS\u2010) treated L6 cells. Treatment with H<jats:sub>2<\/jats:sub>S increased the proliferation and viability of LPS\u2010treated L6 cells. We found that H<jats:sub>2<\/jats:sub>S decreased reactive oxygen species\u2010 (ROS\u2010) induced apoptosis through the mitogen\u2010activated protein kinase (MAPK) signaling pathway in LPS\u2010treated L6 cells. Administration of H<jats:sub>2<\/jats:sub>S alleviated LPS\u2010induced inflammation by mediating the toll\u2010like receptor\u20104 (TLR\u20104)\/nuclear factor\u2010kappa B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) signaling pathway in L6 cells. Furthermore, H<jats:sub>2<\/jats:sub>S improved diaphragmatic function and structure through the reduction of inflammation and apoptosis in the diaphragm of septic rats. In conclusion, these findings indicate that H<jats:sub>2<\/jats:sub>S ameliorates LPS\u2010induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS\/MAPK and TLR4\/NF\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathways. Novel slow\u2010releasing H<jats:sub>2<\/jats:sub>S donors can be designed and applied for the treatment of diaphragm dysfunction.<\/jats:p>","DOI":"10.1155\/2018\/9647809","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T23:31:51Z","timestamp":1527204711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Hydrogen Sulfide Alleviates Lipopolysaccharide\u2010Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS\/MAPK and TLR4\/NF\u2010<i>\u03ba<\/i>B Signaling 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