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Contemporary DNA and protein technologies have facilitated the development of engineered therapeutic monoclonal antibodies in a variety of formats according to the required effector functions. Chimeric, humanized, and human monoclonal antibodies to antigenic\/epitopic myriads with less immunogenicity than animal-derived antibodies in human recipients can be produced<jats:italic>in vitro<\/jats:italic>. Immunotherapy with ready-to-use antibodies has gained wide acceptance as a powerful treatment against both infectious and noninfectious diseases. Influenza, a highly contagious disease, precipitates annual epidemics and occasional pandemics, resulting in high health and economic burden worldwide. Currently available drugs are becoming less and less effective against this rapidly mutating virus. Alternative treatment strategies are needed, particularly for individuals at high risk for severe morbidity. In a setting where vaccines are not yet protective or available, human antibodies that are broadly effective against various influenza subtypes could be highly efficacious in lowering morbidity and mortality and controlling unprecedented epidemic\/pandemic. Prototypes of human single-chain antibodies to several conserved proteins of influenza virus with no Fc portion (hence, no ADE effect in recipients) are available. These antibodies have high potential as a novel, safe, and effective anti-influenza agent.<\/jats:p>","DOI":"10.1155\/2018\/9747549","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T23:31:18Z","timestamp":1527550278000},"page":"1-23","source":"Crossref","is-referenced-by-count":17,"title":["Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy"],"prefix":"10.1155","volume":"2018","author":[{"given":"Urai","family":"Chaisri","sequence":"first","affiliation":[{"name":"Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-8255","authenticated-orcid":true,"given":"Wanpen","family":"Chaicumpa","sequence":"additional","affiliation":[{"name":"Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of 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