{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:49:59Z","timestamp":1770450599710,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":112,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30772689"],"award-info":[{"award-number":["30772689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373563"],"award-info":[{"award-number":["81373563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774238"],"award-info":[{"award-number":["81774238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>To investigate the relationship of MUC1, MUC5AC, and the syndrome of spleen and stomach, 109 subjects (34 peptic ulcer (PU), 62 chronic gastritis (CG), and 13 healthy volunteers (CON)) were included. All the subjects included were surveyed with questionnaire to classify them into damp\u2010heat syndrome of spleen and stomach (DHSS), spleen\u2010qi deficiency syndrome (SQD), and CON, examined by gastric endoscope, and biopsied. Rapid urease and methylene blue staining (MBS) were performed on every subject to diagnose for <jats:italic>Helicobacter pylori<\/jats:italic> (Hp) infection, and both were defined as Hp\u2010positive. Hematoxylin and eosin (HE) staining was performed on every specimen to explore the histomorphology, inflammatory degree, and inflammatory activity of different groups; then Elivision\u2122 plus kit was used to test the expression of MUC1 and MUC5AC. All the results of digital images were reviewed by two experts blindly. The inflammatory degree with Hp infection was higher than those uninfected or CON, but no significant difference was found between DHSS and SQD. And the expressions of MUC5AC with positive Hp was higher than those with negative Hp or CON regardless of the deficiency and solid syndrome of spleen\u2010stomach but not for MUC1. We speculate that the deficiency and solid syndrome of spleen\u2010stomach is a condition like Tai Ji symbol of dynamic equilibrium, showing the higher expression of MUC5AC but no change of MUC1 in the circumstance of Hp infection.<\/jats:p>","DOI":"10.1155\/2018\/9761919","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T23:33:24Z","timestamp":1524526404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MUC1 and MUC5AC Acting on <i>Helicobacter pylori<\/i>\u2010Related Deficiency and Solid Syndrome of Spleen and Stomach"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-8050","authenticated-orcid":false,"given":"Ling","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiwu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.01.004"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1995.0198"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119588"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt079"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs119"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.54"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.003"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12138"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000617"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000117"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2761"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000123168.86324.1b"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02557526"},{"key":"e_1_2_9_16_2","first-page":"S13","article-title":"Zheng: a systems biology approach to diagnosis and treatments","volume":"346","author":"Wang Y.","year":"2014","journal-title":"Science"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/480s87a"},{"key":"e_1_2_9_18_2","first-page":"231","article-title":"Establishement and evaluation for the animal model of damp-heat of spleen-stomach syndrome","author":"Lv G. H.","year":"2005","journal-title":"Journal of Guangzhou University of Traditional Chinese Medicine"},{"key":"e_1_2_9_19_2","first-page":"2178","article-title":"Research on the establishment for the diagnostic standards of spleen-qi deficiency in chronic subepithelial gastritis","author":"Zhou F. S.","year":"2006","journal-title":"Zhong Yi Yao Xue Kan"},{"key":"e_1_2_9_20_2","first-page":"148","article-title":"Profile of gene differential expression in chronic gatritis with deficiency of spleen-qi patients","author":"Chen W. W.","year":"2008","journal-title":"Zhong Guo Bing Li Sheng Li Za Zhi"},{"key":"e_1_2_9_21_2","first-page":"322","article-title":"Study of Th1\/Th2 balance on peripheral blood of chronic gastritis patients with pi-wei damp-heat syndrome","author":"Liang J. K.","year":"2012","journal-title":"Zhong Guo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)60938-7"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-9573.2007.00295.x"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.11.002"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2456-5"},{"key":"e_1_2_9_26_2","first-page":"572","article-title":"Rapid urease test utility for Helicobacter pylori infection diagnosis in gastric ulcer disease","volume":"49","author":"Bermejo F.","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_9_27_2","volume-title":"Guidelines for the Research of New Clinical Drugs of Chinese Medicine (Trial Implementation)","author":"Zheng X. Y.","year":"2002"},{"key":"e_1_2_9_28_2","first-page":"587","article-title":"HSP70 and NF-\u03baB mediating damp-heat syndrome of spleen and stomach of chronic gastritis","author":"Hu L.","year":"2010","journal-title":"Journal of Guangzhou University of Traditional Chinese Medicine"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_9_30_2","first-page":"229","article-title":"The diagnostic standards for the results of immunohistochemistry","author":"Xu L. Z.","year":"1996","journal-title":"China Oncology"},{"key":"e_1_2_9_31_2","first-page":"13","article-title":"Contrastive analysis for the synchronization test of lung cancer gene protein product","author":"Zhao T.","year":"1995","journal-title":"Ai Zheng"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250450"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep01543"},{"key":"e_1_2_9_34_2","first-page":"133","article-title":"Exploration of microcosmic Chinese medicine used by western medicine","volume":"35","author":"Zheng Z. J.","year":"2015","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_9_35_2","first-page":"1174","article-title":"The application of spleen deficiency theory: the topic serie of inheritant and application spleen and stomach theory (4)","author":"Hu L.","year":"2012","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"e_1_2_9_36_2","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994","volume":"61","year":"1994","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00173.x"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.09.003"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.3410\/M4-7"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12198"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2018\/9761919.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2018\/9761919.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/9761919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:58:35Z","timestamp":1722920315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/9761919"}},"subtitle":[],"editor":[{"given":"Victor","family":"Kuete","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/9761919"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9761919","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2018-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9761919"}}