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This included experimental methods (e.g., GFP-labeled tumor and high resolution multispectral cryo-imaging), nonrigid image registration, and interactive visualization of imaging agent targeting. We describe technological details earlier applied to GFP-labeled metastatic tumor targeting by molecular MR (CREKA-Gd) and red fluorescent (CREKA-Cy5) imaging agents. Optimized nonrigid cryo-MRI registration enabled nonambiguous association of MR signals to GFP tumors. Interactive visualization of out-of-RAM volumetric image data allowed one to zoom to a GFP-labeled micrometastasis, determine its anatomical location from color cryo-images, and establish the presence\/absence of targeted CREKA-Gd and CREKA-Cy5. In a mouse with &gt;160 GFP-labeled tumors, we determined that in the MR images every tumor in the lung &gt;0.3\u2009mm<jats:sup>2<\/jats:sup> had visible signal and that some metastases as small as 0.1\u2009mm<jats:sup>2<\/jats:sup> were also visible. More tumors were visible in CREKA-Cy5 than in CREKA-Gd MRI. Tape transfer method and nonrigid registration allowed accurate (&lt;11\u2009<jats:italic>\u03bc<\/jats:italic>m error) registration of whole mouse histology to corresponding cryo-images. Histology showed inflammation and necrotic regions not labeled by imaging agents. This mouse-to-cells multiscale and multimodality platform should uniquely enable more informative and accurate studies of metastatic cancer imaging and therapy.<\/jats:p>","DOI":"10.1155\/2018\/9780349","type":"journal-article","created":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T19:34:36Z","timestamp":1522611276000},"page":"1-16","source":"Crossref","is-referenced-by-count":10,"title":["Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases"],"prefix":"10.1155","volume":"2018","author":[{"given":"Mohammed Q.","family":"Qutaish","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuxian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, 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