{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:34Z","timestamp":1787755474067,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Progres Q25"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2018,9,6]]},"abstract":"<jats:p>The relationship between Hashimoto\u2019s thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule. Totally, 91 patients with primary TC and 182 sex- and age-matched controls were included. Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs. 27% in controls, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>, anti-TG 35% in TC group vs. 21% in controls, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.018<\/mml:mn><\/mml:math>), and the TC group had significantly higher TSH (median 1.88\u2009mIU\/l vs. 1.21\u2009mIU\/l, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Using multiple logistic regression, positive anti-TPO was identified as an independent risk factor (OR 2.21, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.018<\/mml:mn><\/mml:math>), while spontaneously suppressed <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi mathvariant=\"normal\">T<\/mml:mi><mml:mi mathvariant=\"normal\">S<\/mml:mi><mml:mi mathvariant=\"normal\">H<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.5<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mi mathvariant=\"normal\">m<\/mml:mi><mml:mi mathvariant=\"normal\">I<\/mml:mi><mml:mi mathvariant=\"normal\">U<\/mml:mi><mml:mo>\/<\/mml:mo><mml:mi mathvariant=\"normal\">l<\/mml:mi><\/mml:math> was a protective factor (OR 0.3, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) against TC. In conclusion, nodules in subjects with positive antithyroid antibodies could be considered to have a higher risk of malignancy. However, based on our results, it is not possible to declare that TC is triggered by HT.<\/jats:p>","DOI":"10.1155\/2018\/9793850","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T19:51:38Z","timestamp":1536263498000},"page":"1-6","source":"Crossref","is-referenced-by-count":18,"title":["Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study"],"prefix":"10.1155","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-4537","authenticated-orcid":true,"given":"Jan","family":"Kr\u00e1tk\u00fd","sequence":"first","affiliation":[{"name":"3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Je\u017ekov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikul\u00e1\u0161","family":"Kos\u00e1k","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"V\u00edtkov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Bart\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161","family":"Mr\u00e1z","sequence":"additional","affiliation":[{"name":"Dialectology Center, Institute of Clinical and Experimental Medicine, V\u00edde\u0148sk\u00e1 1958, 140 21 Praha 4, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jind\u0159ich","family":"Luk\u00e1\u0161","sequence":"additional","affiliation":[{"name":"Department of ENT, Surgery of Head and Neck, Na Homolce Hospital, Roentgenova 2\/37, 150 00 Praha 5, Czech 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