{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T05:01:14Z","timestamp":1785042074882,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Bacterial meningitis during the perinatal period may cause long\u2010term neurological deficits. The study investigated whether bacterial lipopolysaccharide (LPS) derived from <jats:italic>E. coli.<\/jats:italic> led to neuronal apoptosis with an impaired performance of long\u2010term cognitive function involving the activation of histone modification in the TNF\u2010<jats:italic>\u03b1<\/jats:italic> gene promoter. Further, we looked into the therapeutic efficacy of granulocyte colony\u2010stimulating factor (G\u2010CSF) in a neonatal brain suffering from perinatal bacterial meningitis. We applied the following research techniques: neurobehavioral tasks, confocal laser microscopy, chromatin immunoprecipitation, and Western blotting. At postnatal day 10, the animals were subjected to LPS and\/or G\u2010CSF. The target brain tissues were then collected at P17. Some animals (P45) were studied using neurobehavioral tasks. The LPS\u2010injected group revealed significantly increased expression of NF\u2010<jats:italic>\u03ba<\/jats:italic>B phosphorylation and trimethylated H3K4 in the <jats:italic>TNFA<\/jats:italic> gene promoter locus. Furthermore, the caspase\u20103, neuronal apoptosis expression, and an impaired performance in cognitive functions were also found in our study. Such deleterious outcomes described above were markedly alleviated by G\u2010CSF therapy. This study suggests that selective therapeutic action sites of G\u2010CSF through epigenetic regulation in the <jats:italic>TNFA<\/jats:italic> gene promoter locus may exert a potentially beneficial role for the neonatal brain suffering from perinatal bacterial\u2010induced meningitis.<\/jats:p>","DOI":"10.1155\/2018\/9797146","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T23:37:25Z","timestamp":1517528245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Granulocyte Colony\u2010Stimulating Factor Alleviates Bacterial\u2010Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification"],"prefix":"10.1155","volume":"2018","author":[{"given":"Yung-Ning","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsun","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hwa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-8527","authenticated-orcid":false,"given":"Yu-Chen S. H.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jau-Ling","family":"Suen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-8546","authenticated-orcid":false,"given":"San-Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-013-0465-z"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(99)80066-4"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000193292.09894.b7"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00471.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80003-X"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.03.008"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01035-1"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-28-09403.2003"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00785.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2392-04.2004"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.12.022"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs156"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.05.003"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.01.045"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199448050-00007"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/481392"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000145998.11686.ED"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142616.07367.66"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.506816"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3496fje"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23559"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2013.04.011"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.01.144"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02429-06"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1530230"},{"key":"e_1_2_9_26_2","first-page":"51","article-title":"Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction","volume":"27","author":"Wang Y.","year":"2006","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.04.001"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2017.0916"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/759293"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.12.002"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901011"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930000.51.S49"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.11.007"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1202618"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2004.11.009"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3507290"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1128"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.103531"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023660"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260001"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81334-3"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02545-9"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1299.012"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199908000-00001"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.10.JNS161109"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000208205.26253.96"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199905000-00051"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000057814.70180.17"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.2741\/2095"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000179196.10032.dd"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408258102"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00057-4"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182324424"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-153"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/9797146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/9797146.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2018\/9797146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T11:15:44Z","timestamp":1723029344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2018\/9797146"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1155\/2018\/9797146"],"URL":"https:\/\/doi.org\/10.1155\/2018\/9797146","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9797146"}}