{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:31:13Z","timestamp":1755693073155,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T00:00:00Z","timestamp":1570924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2019,10,13]]},"abstract":"<jats:p>Pure white cell aplasia (PWCA) is a rare manifestation of thymoma. It is characterized by agranulocytosis with absent myeloid precursors in the bone marrow and normal hematopoiesis for other cell lines. Here we describe a 65-year-old female patient who presented with three days of fever and night sweat. Chest CT revealed an anterior mediastinal mass. A biopsy of the mass confirmed a diagnosis of thymoma mixed type A and B2. The patient developed a severe neutropenia, and her bone marrow revealed significantly decreased neutrophil-lineage cells, rare to absent B cells, and defective T cells, consistent with PWCA. Following thymectomy, a complete resolution of PWCA was achieved via multimodality therapy of intravenous immunoglobulins, granulocyte colony-stimulating factor, and immunosuppressant. This report highlights the care complexity regarding treatment choices and decision to perform thymectomy in patients presenting with PWCA.<\/jats:p>","DOI":"10.1155\/2019\/1024670","type":"journal-article","created":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T19:30:37Z","timestamp":1570995037000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["A Rare Complication of Thymoma: Pure White Cell Aplasia in Good\u2019s Syndrome"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-035X","authenticated-orcid":true,"given":"Kim","family":"Uy","sequence":"first","affiliation":[{"name":"University of Minnesota, Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Levin","sequence":"additional","affiliation":[{"name":"University of Minnesota, Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Mroz","sequence":"additional","affiliation":[{"name":"University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faqian","family":"Li","sequence":"additional","affiliation":[{"name":"University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-5687","authenticated-orcid":true,"given":"Surbhi","family":"Shah","sequence":"additional","affiliation":[{"name":"University of Minnesota, Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/jto.0b013e3181f1f62d"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.01.006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.1.12"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1182\/blood.V60.4.968.968","volume":"60","year":"1982","journal-title":"Blood"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0791-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/jto.0b013e3181f20dab"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.208234"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0014-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1532\/ijh97.06018"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412y.0000000043"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00023.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0128-9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.08.013"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(97)70283-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286161"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9644-1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.07.025"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.34.3707"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/1024670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/1024670.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2019\/1024670.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T19:30:49Z","timestamp":1570995049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2019\/1024670\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,13]]},"references-count":18,"alternative-id":["1024670","1024670"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1024670","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2019,10,13]]}}}