{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:34:54Z","timestamp":1747190094251,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015362","name":"Amicus Therapeutics, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015362","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2019,12,22]]},"abstract":"<jats:p>Our patient was a 37-year-old woman with Fabry disease (<jats:italic>GLA<\/jats:italic> p.R112H) with a medical history of recurrent headache, nausea, vomiting, vertigo, and tobacco use (20 cigarettes\/day). Fabry disease was diagnosed in 2005 when she experienced proteinuria, preeclampsia, and hypertension (201\/130\u2009mm Hg) during pregnancy (delivered 50\u2009cm, 3.4\u2009kg healthy boy; <jats:italic>GLA <\/jats:italic>wild type [WT]). Enzyme replacement therapy was initiated in 2009. The patient enrolled in the phase 3 ATTRACT trial (ClinicalTrials.gov; <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01218659\">NCT01218659<\/jats:ext-link>) and started migalastat in May 2012 while taking hormonal contraceptives. Two years after initiating migalastat, the patient had proteinuria (2166\u2009mg\/24\u2009h) without hypertension (131\/68\u2009mm Hg), which persisted (788\u2009mg\/24\u2009h a month later). Kidney biopsy results were consistent with existing Fabry disease. A serum pregnancy test and ultrasound confirmed pregnancy (18 weeks\u2019 gestation). Migalastat and hormonal contraceptives were stopped; the patient continued to smoke. Fetal MRI was normal at ~29 weeks\u2019 gestation. In October 2014, at 37+ weeks\u2019 gestation, the patient delivered a 45-cm, 2.29-kg healthy girl (<jats:italic>GLA<\/jats:italic> WT). Excepting low birth weight, which may be related to the patient\u2019s smoking, pregnancy outcome was normal despite exposure to migalastat for 18 weeks. Migalastat therapy during pregnancy is not advised.<\/jats:p>","DOI":"10.1155\/2019\/1030259","type":"journal-article","created":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T23:30:17Z","timestamp":1577057417000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy Outcome after Exposure to Migalastat for Fabry Disease: A Clinical Report"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-1007","authenticated-orcid":true,"given":"Natalja","family":"Haninger-Vacariu","sequence":"first","affiliation":[{"name":"Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"El-Hadi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Pauler","sequence":"additional","affiliation":[{"name":"Department of Medicine I, University Hospital St. P\u00f6lten, Lower Austria, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Foretnik","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-543X","authenticated-orcid":true,"given":"Renate","family":"Kain","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Proh\u00e1szka","sequence":"additional","affiliation":[{"name":"Semmelweis University, Research Laboratory, Third Department of Internal 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