{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:25:08Z","timestamp":1760217908010,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,5,14]]},"abstract":"<jats:p>Single injections in the anterior region of the thoracic paravertebral space (TPVS) have been reported to generate a multisegmental longitudinal spreading pattern more frequently than those in the posterior region of the TPVS. In this trial, we examined the hypothesis that a continuous thoracic paravertebral block (TPVB) administered through a catheter inserted into the anterior region of the TPVS allows a wider sensory block dispersion. Fifty consecutive patients undergoing video-assisted thoracic surgery were enrolled. Before the surgery, an infusion catheter was inserted into the TPVS through a needle placed adjacent to either the parietal pleura (group A) or internal intercostal membrane (group P) using an ultrasound-guided intercostal transverse approach according to a randomized allocation schedule. A chest radiograph was obtained postoperatively after injection of 10 mL of radiopaque dye through the catheter. Thereafter, 20 mL of 0.375% levobupivacaine was injected via the catheter, followed by commencement of continuous TPVB with 0.25% levobupivacaine at 8 mL\/h. The primary outcome was the number of blocked dermatomes at 24 h after surgery. The secondary outcomes included radiopaque dye spreading patterns, the number of segments reached by the radiopaque dye, the number of blocked dermatomes at 2 h after surgery, and pain scores. The median (interquartile range [range]) number of blocked dermatomes 24 h after surgery was 3 (2.75\u20134 [1\u20136]) in group A (n = 22) and 2 (1.5\u20133 [0\u20137]) in group P (n = 25; p = 0.037). No significant differences in the other outcomes were found between the groups. In conclusion, a continuous TPVB administered using a catheter supposedly inserted into the anterior region of the TPVS allows a wider sensory block dispersion than a catheter inserted into the posterior region of the TPVS. This trial is registered with the UMIN Clinical Trials Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000021255\">UMIN000018578<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2019\/1051629","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T19:31:15Z","timestamp":1557862275000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Catheter Tip Location on the Spread of Sensory Block Caused by a Continuous Thoracic Paravertebral Block: A Prospective, Randomized, Controlled, Double-Blind Study"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-894X","authenticated-orcid":true,"given":"Takayuki","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Kansai Medical University Hospital, Hirakata City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Niigata City General Hospital, Niigata City, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nagaoka Chuo General Hospital, Nagaoka City, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-5625","authenticated-orcid":true,"given":"Tatsuo","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kansai Medical University Hospital, Hirakata City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00033"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1995.tb15092.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000631"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12531"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.03189_1.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31824451cb"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03705.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000747"},{"issue":"3","key":"9","first-page":"996","volume":"109","year":"2009","journal-title":"Anesthesia & Analgesia"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep015"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-016-2170-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-017-1857-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13216"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2016.05.004"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.1993.tb00042.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318289465f"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq309"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000945"},{"journal-title":"Regional Anesthesia and Pain Medicine","year":"2019","key":"19"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1051629.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1051629.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1051629.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T19:31:18Z","timestamp":1557862278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/1051629\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":19,"alternative-id":["1051629","1051629"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1051629","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2019,5,14]]}}}