{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:05:03Z","timestamp":1784340303373,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T00:00:00Z","timestamp":1569110400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General Research Fund","award":["17114715"],"award-info":[{"award-number":["17114715"]}]},{"name":"Research Grant Council of Hong Kong","award":["17114715"],"award-info":[{"award-number":["17114715"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2019,9,22]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease. <jats:italic>Materials and Methods<\/jats:italic>. Thirty C57BL\/6N mice were randomly divided into three groups (<jats:italic>N<\/jats:italic>\u2009=\u200910). All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA\/Dx) for 12\u2009weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed and the mandibles were collected for radiological and histological examinations. <jats:italic>Results<\/jats:italic>. Microcomputed tomography (<jats:italic>\u03bc<\/jats:italic>-CT) examination showed significantly reduced periapical bone resorption in the ZA\/Dx group and decreased periodontal bone resorption in both ZA and ZA\/Dx groups. Higher bone mineral density (BMD) and strengthened microstructure were found in ZA and ZA\/Dx groups. More empty lacunae were found in ZA and ZA\/Dx groups. <jats:italic>Conclusions<\/jats:italic>. Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ.<\/jats:p>","DOI":"10.1155\/2019\/1271492","type":"journal-article","created":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T19:30:24Z","timestamp":1569180624000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6959-5589","authenticated-orcid":true,"given":"Nian Jing","family":"Rao","sequence":"first","affiliation":[{"name":"Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-5326","authenticated-orcid":true,"given":"Jing Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Helm","sequence":"additional","affiliation":[{"name":"Department of Medicine and Orofacial Surgery, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-0208","authenticated-orcid":true,"given":"Li Wu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.12.011"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.37"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2014.46"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/421431"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650020617"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650081106"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0299-3"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.2757-7861.2008.00014.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090592"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12502"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.379"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-015-0020-6"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.01.011"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.12.025"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200209000-00004"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.007"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.2147\/cia.s67726"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00878.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1560175"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.04.013"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17150"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.08.008"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2007.09.002"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1271492.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1271492.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/1271492.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T19:30:27Z","timestamp":1569180627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/1271492\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,22]]},"references-count":23,"alternative-id":["1271492","1271492"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1271492","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,22]]}}}