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To evaluate the clinical efficacy and safety of Kangfuxin liquid (KFX) combined with proton pump inhibitors (PPIs) in the treatment of gastric ulcer (GU). <jats:italic>Materials and Methods<\/jats:italic>. Electronic databases including PubMed, Wanfang, CNKI, VIP, Embase, Cochrane Library, and CBM were examined for appropriate articles without language limitations on key words before March 10, 2019. RevMan 5.3 software was applied to execute outcome assessment and finish the meta-analysis. <jats:italic>Results<\/jats:italic>. 22 articles involving 2,024 patients with a gastric ulcer were selected. Total efficacy rate and efficacy rate of gastroscopy were significantly enhanced for the combination of KFX with PPIs compared to those of PPI treatment alone (OR\u2009=\u20096.95, 95% CI: 4.87, 9.91, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:mrow><\/mml:math>; OR\u2009=\u20092.96, 95% CI: 1.98, 4.42, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:mrow><\/mml:math>, respectively). Same results were found for different PPIs in combination on total efficacy rate, respectively. The combination also significantly reduced the adverse events (OR\u2009=\u20090.39, 95% CI: 0.22, 0.70, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>). In addition, KFX combined with PPI could suppress the inflammation (MD\u2009=\u2009\u22126.11, 95% CI: \u22127.45, \u22124.77, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:mrow><\/mml:math>), reduce the recurrence rate (OR\u2009=\u20090.31, 95% CI: 0.14, 0.70, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:mrow><\/mml:math>), and enhance the clearance rate of <jats:italic>Helicobacter pylori<\/jats:italic> (HP, OR\u2009=\u20093.76, 95% CI: 1.80, 7.87, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0004<\/mml:mn><\/mml:mrow><\/mml:math>). It seemed like the combination would influence immune function by increasing levels of T-lymphocyte subsets CD4 and CD8 but not CD3 (MD\u2009=\u20092.40, 95% CI: 1.25, 3.55, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:mrow><\/mml:math>); MD\u2009=\u200925.72, 95% CI: 14.55, 36.90, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.00001<\/mml:mn><\/mml:mrow><\/mml:math>; MD\u2009=\u20090.72, 95% CI: \u22120.66, 2.09, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.31<\/mml:mn><\/mml:mrow><\/mml:math>, respectively). <jats:italic>Conclusion<\/jats:italic>. KFX combined with PPIs in treatment of patients with GU could improve the total efficacy rate and efficacy rate of gastroscopy and reduce adverse events and the recurrence rate. However, the results of this study should be handled with care due to the limitations. Several rigorous RCTs are in need to confirm these findings.<\/jats:p>","DOI":"10.1155\/2019\/1324969","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T19:36:05Z","timestamp":1569872165000},"page":"1-13","source":"Crossref","is-referenced-by-count":15,"title":["Therapeutic Efficacy of Kangfuxin Liquid Combined with PPIs in Gastric Ulcer"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-4722","authenticated-orcid":true,"given":"Jun-Bo","family":"Zou","sequence":"first","affiliation":[{"name":"Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research; Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research; Pharmacy College, Shaanxi 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