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In this study, we show that ANTXR1<jats:sup>+<\/jats:sup> cells are not only detectable across a panel of 7 PDAC patient-derived xenograft primary cultures but ANTXR1 expression significantly increased in CSC-enriched 3D sphere cultures. Importantly, ANTXR1<jats:sup>+<\/jats:sup> cells also coexpressed other known PaCSC markers such as CD44, CD133, and autofluorescence, and ANTXR1<jats:sup>+<\/jats:sup> cells displayed enhanced CSC functional and molecular properties, including increased self-renewal and expression of pluripotency-associated genes, compared to ANTXR1<jats:sup>-<\/jats:sup> cells. 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