{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:51:03Z","timestamp":1740156663866,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:00:00Z","timestamp":1559433600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/21\/B\/NZ5\/01902"],"award-info":[{"award-number":["2016\/21\/B\/NZ5\/01902"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2019,6,2]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Atherosclerosis and bone metabolism share similar molecular and cellular mechanisms. This study aims to evaluate (1) serum concentration of osteogenesis\/osteolysis factors panel (Dickkopf-related protein 1 (DKK-1), TNF-<jats:italic>\u03b1<\/jats:italic>, <jats:italic>N<\/jats:italic>-terminal atrial natriuretic peptide (NT-proANP), thrombospondin-2 (TSP-2), osteoprotegerin (OPG), osteocalcin (OCN), osteopontin (OPN), fibroblast growth factor 23 (FGF-23), soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), proprotein convertase subtilisin\/kexin type 9 (PCSK9)), (2) serum expression levels of micro-RNA- (miR-) 24-1 and miR-6802, and (3) assess their correlation with myocardial injury and LV remodeling and function in the acute phase of STEMI and after 3\u2009months. <jats:italic>Methods<\/jats:italic>. Study enrolled 25 STEMI patients (mean age 55.4\u2009\u00b1\u20098.96\u2009years). Blood samples were collected 4\u2009days and 3\u2009months after myocardial infarction. Serum concentrations of osteogenesis\/osteolysis factors were measured using the Luminex assay. Analysis of miR-24-1, and miR-6802 expression was performed with qPCR. LV function and remodeling were assessed by MRI during index hospitalization and 3\u2009months later. <jats:italic>Results<\/jats:italic>. There were no significant differences in serum levels of osteogenesis\/osteolysis factors and expression of miR-24-1 and miR-6802 between the acute phase and 3-month follow-up. The levels were similar in patients with at least \u22655% improvement of LVEF (<jats:italic>n<\/jats:italic>\u2009=\u200910) and those without improvement. There was a negative correlation between the OPG serum level and LVEF during the acute phase of myocardial infarction. <jats:italic>Conclusions<\/jats:italic>. In STEMI patients, serum concentrations of osteogenesis\/osteolysis factors, as well as miR-24-1 and miR-6802 expression, do not change significantly within the 3-month follow-up and are not correlated with LV remodeling and function.<\/jats:p>","DOI":"10.1155\/2019\/1420717","type":"journal-article","created":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T19:31:30Z","timestamp":1559503890000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["Serum Concentrations of Osteogenesis\/Osteolysis-Related Factors and Micro-RNA Expression in ST-Elevation Myocardial Infarction"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-9100","authenticated-orcid":true,"given":"Tomasz","family":"Jadczyk","sequence":"first","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"},{"name":"Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-6090","authenticated-orcid":true,"given":"Tomasz","family":"Francuz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5343-1205","authenticated-orcid":true,"given":"Wojciech","family":"Garczorz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Kimsa-Furdzik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mieczyslaw","family":"Dutka","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Biochemistry and Molecular Biology, University of Bielsko-Biala, Bielsko-Biala, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Gaik","sequence":"additional","affiliation":[{"name":"American Heart of Poland, Dabrowa Gornicza, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-4492","authenticated-orcid":true,"given":"Katarzyna","family":"Gruszczynska","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Syzdol","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Wanha","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-0907","authenticated-orcid":true,"given":"Radoslaw","family":"Kurzelowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Fluder","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenek","family":"Starek","sequence":"additional","affiliation":[{"name":"Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic"},{"name":"1st Department of Internal Medicine\u2014Cardioangiology, St. Anne's University Hospital Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3681-5207","authenticated-orcid":true,"given":"Wojciech","family":"Wojakowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.050711"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn303"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp391"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22221"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305402"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1934"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154740"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1042\/cs20050058"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2008.091"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.12.031"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.117"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.206714"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03790.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.44.833"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12792"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.5551\/jat.25718"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156965"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.4158\/ep14229.or"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.742"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310520"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.026"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.003486"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.115.002341"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.109.189761"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.05.015"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-13-1221"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106294"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv637"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1159\/000328869"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.117.309189"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15045774"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.040"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719843806"},{"issue":"6","key":"34","first-page":"627","volume":"61","year":"2013","journal-title":"Minerva Cardioangiol"}],"container-title":["Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2019\/1420717.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2019\/1420717.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2019\/1420717.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T19:31:33Z","timestamp":1559503893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crp\/2019\/1420717\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,2]]},"references-count":34,"alternative-id":["1420717","1420717"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1420717","relation":{},"ISSN":["2090-8016","2090-0597"],"issn-type":[{"type":"print","value":"2090-8016"},{"type":"electronic","value":"2090-0597"}],"subject":[],"published":{"date-parts":[[2019,6,2]]}}}