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We performed electronic and manual searches including English and Chinese databases published before April 2019, with the use of mesh term and free text of \u201cnonalcoholic fatty liver disease\u201d and \u201cprobiotics.\u201d Clinical trials evaluating the efficacy of probiotic therapy in NAFLD patients were included according to the eligibility criteria. With the use of random effects models, clinical outcomes were presented as weighted mean difference (WMD) with 95% confidence interval (CI), while heterogeneity and meta-regression were also assessed. <jats:italic>Results<\/jats:italic>. 28 clinical trials enrolling 1555 criterion proven NAFLD patients with the use of probiotics from 4 to 28 weeks were included. Overall, probiotic therapy had beneficial effects on body mass index (WMD: -1.46, 95% CI: [-2.44, -0.48]), alanine aminotransferase (WMD: -13.40, 95% CI: [-17.03, -9.77]), aspartate transaminase (WMD: -13.54, 95% CI: [-17.86, -9.22]), gamma-glutamyl transpeptidase (WMD: -9.88, 95% CI: [-17.77, -1.99]), insulin (WMD: -1.32, 95% CI: [-2.43, -0.21]), homeostasis model assessment-insulin resistance (WMD: -0.42, 95% CI: [-0.73, -0.12]), and total cholesterol (WMD: -15.38, 95% CI: [-26.50, -4.25]), but not in fasting blood sugar, lipid profiles, or tumor necrosis factor-alpha. <jats:italic>Conclusion<\/jats:italic>. The systematic review and meta-analysis support that probiotics are superior to placebo in NAFLD patients and could be utilized as a common complementary therapeutic approach.<\/jats:p>","DOI":"10.1155\/2019\/1484598","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T18:30:28Z","timestamp":1576089028000},"page":"1-19","source":"Crossref","is-referenced-by-count":75,"title":["Systematic Review with Meta-Analysis: The Effects of Probiotics in Nonalcoholic Fatty Liver Disease"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-534X","authenticated-orcid":true,"given":"Meng-Wei","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha 410013, 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