{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:32:07Z","timestamp":1790220727242,"version":"4.1.0"},"reference-count":152,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001209","name":"KNIGHTS TEMPLAR EYE FOUNDATION","doi-asserted-by":"publisher","award":["R01 DA018928"],"award-info":[{"award-number":["R01 DA018928"]}],"id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DA018928"],"award-info":[{"award-number":["R01 DA018928"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"<jats:p>Experience remodels cortical connectivity during developmental windows called critical periods. Experience-dependent regulation of synaptic strength during these periods establishes circuit functions that are stabilized as critical period plasticity wanes. These processes have been extensively studied in the developing visual cortex, where critical period opening and closure are orchestrated by the assembly, maturation, and strengthening of distinct synapse types. The synaptic specificity of these processes points towards the involvement of distinct molecular pathways. Attractive candidates are pre- and postsynaptic transmembrane proteins that form adhesive complexes across the synaptic cleft. These synapse-organizing proteins control synapse development and maintenance and modulate structural and functional properties of synapses. Recent evidence suggests that they have pivotal roles in the onset and closure of the critical period for vision. In this review, we describe roles of synapse-organizing adhesion molecules in the regulation of visual critical period plasticity and we discuss the potential they offer to restore circuit functions in amblyopia and other neurodevelopmental disorders.<\/jats:p>","DOI":"10.1155\/2019\/1538137","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T19:30:22Z","timestamp":1567539022000},"page":"1-9","source":"Crossref","is-referenced-by-count":26,"title":["Emerging Roles of Synapse Organizers in the Regulation of Critical Periods"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6653-8645","authenticated-orcid":true,"given":"Adema","family":"Ribic","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-1514","authenticated-orcid":true,"given":"Thomas","family":"Biederer","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA"},{"name":"Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009022"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1976.040.01.054"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1977.0050"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910102"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04388.1999"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-08-03549.1993"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09896.1998"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903090109"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902960210"},{"issue":"5","key":"10","first-page":"488","volume":"88","year":"1984","journal-title":"American Journal of Mental Deficiency"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05337-6"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108270109"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.7.619"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01181531"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90379-2"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1126\/science.8511592"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960520)369:1<64::AID-CNE5>3.0.CO;2-I"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.069"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nature12485"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0935-16.2016"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.08.033"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.013"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/nature12015"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63327-9.00001-1"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.002"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/s13064-018-0105-x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.09.006"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2639"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/35004582"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5393.1504"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-17-06695.2003"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2013.04.001"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00495.2018"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2504-16.2016"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2264-4"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400694111"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2233-09.2010"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072699"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.071"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421844112"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3446"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05558"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1253-18.2019"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0963-3"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-014-0075-9"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1101\/155465"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02798"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183962"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy108"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.054"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7931693"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00307"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.014"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.1"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.12.026"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04007-x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3023"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0394-12.2012"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202173"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.028"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau8977"},{"issue":"4, article a005694","key":"62","volume":"4","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.006"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001727"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.09.040"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135302"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80877-6"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072356"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6688-2_3"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.017"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1038\/srep24241"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.003"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201003007"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.06.026"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7969"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1038\/nn1074"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.043002.094940"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.003"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.023"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27443"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.015"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1126\/science.1107470"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804007106"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.06.005"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.034"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.006"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04047"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21773"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710172105"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2739-07.2007"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0189-16.2016"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23452"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.336"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.157032"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.03.004"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201205041"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2009.09.010"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4612"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525586113"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.029"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2016.10.003"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0470-10.2010"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803280115"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201101072"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.002"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4327082"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq145"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22485"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1876-2"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-6-43"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2351-16.2016"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1038\/nn2008"},{"issue":"4","key":"113","first-page":"297","volume":"12","year":"2001","journal-title":"Reviews in the Neurosciences"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00022"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-013-0979-2"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2009.02.010"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2005.07.031"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401200101"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.17m11857"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.07.007"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/921680"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8481"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195320"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1126\/science.1150516"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27345"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1312"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.072"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0545-14.2014"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.04.055"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4430"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1101\/525014"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0431-2"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1499-0"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00082"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3845-11.2012"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6355"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2010.00004"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.07.033"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/286073"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4225"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.04.029"},{"key":"142","first-page":"11","volume":"2012","year":"2012","journal-title":"Cerebrum"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20974"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr039"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1439"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(09)17534-9"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1509-3"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0654-5"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.035"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8999"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4366"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.032"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2019\/1538137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2019\/1538137.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2019\/1538137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T00:43:19Z","timestamp":1569112999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/np\/2019\/1538137\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":152,"alternative-id":["1538137","1538137"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1538137","relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"value":"2090-5904","type":"print"},{"value":"1687-5443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}