{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:35:39Z","timestamp":1747190139861,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2019,8,6]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Decreased graft patency after off-pump coronary artery bypass grafting (OPCAB) leads to substantial increases in cardiac events. However, there is paucity of data on efficacy and safety of perioperative statin therapy for OPCAB populations.<jats:italic> Methods<\/jats:italic>. 582 patients undergoing OPCAB in a single-institution database (October 1, 2009\u2013September 30, 2012) were stratified by perioperative continuation of statin therapy (CS group, n=398) or not (DS group, n=184). Inverse probability weighted propensity adjustment was used to account for treatment assignment bias, resulting in a well-matched cohort. Primary outcomes were graft patency at an average of five days after operation and in-hospital mortality. Secondary outcomes included intraoperative blood loss, liver, and renal functions.<jats:italic> Results<\/jats:italic>. No in-hospital death occurred in this study. Early graft patency rates after OPCAB were 98.4% (1255 of 1275 grafts) in the CS group and 98.0% (583 of 595 grafts,<jats:italic> P<\/jats:italic>=0.486) in the DS group. Secondary outcomes showed a reduction in blood loss during operation (438.53\u2009mL versus 480.47\u2009mL,<jats:italic> P<\/jats:italic>=0.01). Continuation of statin therapy is associated with alanine transaminase (ALT) elevation (49.67 U\/L versus 34.52 U\/L,<jats:italic> P<\/jats:italic>&lt;0.001), as well as aspartate transaminase (33.54 U\/L versus 28.10 U\/L,<jats:italic> P<\/jats:italic>&lt;0.001). Abnormal ALT elevation was observed in 8.9% of the CS group and 3.1% in DS (odds ratio 3.06, 95% confidence interval, 1.77 to 5.29,<jats:italic> P<\/jats:italic>&lt;0.001). There was no significant difference in estimated glomerular filtration rate (76.28\u2009mL\/min\/1.73m<jats:sup>2<\/jats:sup> versus 76.13\u2009mL\/min\/1.73m<jats:sup>2<\/jats:sup>,<jats:italic> P=<\/jats:italic>0.90). Subgroup analyses suggested that graft occlusion was less common in CS than in DS group among smoking patients (odds ratio 0.41, 95% confidence interval, 0.20 to 0.86,<jats:italic> P<\/jats:italic>=0.026).<jats:italic> Conclusions<\/jats:italic>. Perioperative continuation of statin therapy did not improve early graft patency in OPCAB patients. A lower risk of graft occlusion was observed among smoking patients. Continuous statin use correlated with liver function elevation (Clinical Trials.gov number, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/results?term=NCT+01268917&amp;Search=Search\">NCT 01268917<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2019\/1582183","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T19:30:30Z","timestamp":1565119830000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Does Early Graft Patency Benefit from Perioperative Statin Therapy? A Propensity Score-Matched Study of Patients Undergoing Off-Pump Coronary Artery Bypass Surgery"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-0110","authenticated-orcid":true,"given":"Shanglin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengchao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baotong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-1510","authenticated-orcid":true,"given":"Hansong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of 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