{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:02:14Z","timestamp":1778691734873,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T00:00:00Z","timestamp":1558828800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K10735"],"award-info":[{"award-number":["15K10735"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2019,5,26]]},"abstract":"<jats:p>Background: Superficial myofibroblastoma (SMF) is a very rare benign mesenchymal tumor in the female lower genital tract. Only 46 cases have been reported in the English language literature, among which only 7 cases arose in the vulva. Sometimes SMF histologically mimics aggressive angiomyxoma (AA) in which massive myxoid change in stroma is characteristic. We herein report a case of vulvar SMF with prominent myxoid stroma and review the literature with the emphasis on the differential diagnosis of SMF and AA. Case presentation: a 37-year-old woman presented with a painless mass in the vulva. Magnetic resonance imaging (MRI) showed a well-circumscribed 7 cm mass in the subcutis of the vulva. The tumor was resected. Histopathologically, the tumor was characterized by sparsely populated spindle-shaped cells in the fibromyxoid stroma. Thin-walled blood vessels were detected. Mitoses or pleomorphism was not found. Tumor cells were positive for vimentin, ER, PgR, and desmin. Some cells were positive for alpha-SMA and CD34. All cells were negative for S100 protein. Conclusions: because SMF and AA show different clinical prognoses, distinguishing SMF from AA is important. However, SMF may share many common histological features with AA: superficial localization (above fascia), sharp borderline from adjacent tissue, expansive growth pattern; a specific vascular pattern will lead to an accurate diagnosis of SMF. Familiarization with the histological characteristics of the two entities will help to make a prognostic prediction.<\/jats:p>","DOI":"10.1155\/2019\/1582714","type":"journal-article","created":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T19:30:23Z","timestamp":1558899023000},"page":"1-5","source":"Crossref","is-referenced-by-count":11,"title":["Superficial Myofibroblastoma in the Vulva Mimicking Aggressive Angiomyxoma: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0675-3794","authenticated-orcid":true,"given":"Wei-Xia","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Integrated Diagnostic Pathology, Nippon Medical School, Japan"},{"name":"Department of Pathology, Misato Kenwa Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-7061","authenticated-orcid":true,"given":"Ryuichi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Integrated Diagnostic Pathology, Nippon Medical School, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Kure","sequence":"additional","affiliation":[{"name":"Department of Integrated Diagnostic Pathology, Nippon Medical School, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shinyurigaoka General Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenya","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Integrated Diagnostic Pathology, Nippon Medical School, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.25588"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02063.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/00313020500058284"},{"key":"4","first-page":"165","volume":"48","year":"2007","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"5","first-page":"1093","volume":"123","year":"2010","journal-title":"Chinese Medical Journal"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.04.027"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1148\/rg.272065082"}],"container-title":["Case Reports in Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2019\/1582714.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2019\/1582714.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2019\/1582714.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T19:30:24Z","timestamp":1558899024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cripa\/2019\/1582714\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,26]]},"references-count":7,"alternative-id":["1582714","1582714"],"URL":"https:\/\/doi.org\/10.1155\/2019\/1582714","relation":{},"ISSN":["2090-6781","2090-679X"],"issn-type":[{"value":"2090-6781","type":"print"},{"value":"2090-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,26]]}}}