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Although kidney transplantation may improve survival and quality of life, its long-term results are hampered by immune- and\/or non-immune-mediated complications. Thus, the identification of transplanted patients with a higher risk of posttransplant complications has become a big challenge for public health. However, current biomarkers of posttransplant complications have a poor predictive value, rising the need to explore novel approaches for the management of transplant patient. In this review we summarize the emerging literature about DNA methylation in kidney transplant complications, in order to highlight its perspectives toward biomarker identification. In the forthcoming future the monitoring of DNA methylation in kidney transplant patients could become a plausible strategy toward the prevention and\/or treatment of kidney transplant complications.<\/jats:p>","DOI":"10.1155\/2019\/1602539","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T18:31:17Z","timestamp":1547577077000},"page":"1-8","source":"Crossref","is-referenced-by-count":14,"title":["Unveiling the Role of DNA Methylation in Kidney Transplantation: Novel Perspectives toward Biomarker Identification"],"prefix":"10.1155","volume":"2019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-8162","authenticated-orcid":true,"given":"Antonella","family":"Agodi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University of Catania, Via S. 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